Tbio ATP11B Probable phospholipid-transporting ATPase IF

Protein Summary

Description

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane. P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

Uniprot Accession IDs

• Q9Y2G3
• Q96FN1
• Q9UKK7

Gene Name

• ATP11B

Ensembl ID

• ENST00000323116
• ENSP00000321195
• ENSG00000058063

Symbol

• ATPIF
• ATPIR
• KIAA0956
• ATPIF
• ATPIR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
metabolite	0.98
transcription factor perturbation	0.97
protein domain	0.92
transcription factor binding site profile	0.75

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Probable Phospholipid-transporting Atpase If

Protein / Hydrolase / Probable Phospholipid-transporting Atpase If

DTO Classes

Protein / Transporter / P-type Atpases / Phospholipid-transporting Atpases / Probable Phospholipid-transporting Atpase If

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.15   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.15   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0