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Tbio
ATP11B
Probable phospholipid-transporting ATPase IF

Protein Summary
Description
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane. P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323116
  • ENSP00000321195
  • ENSG00000058063

Symbol
  • ATPIF
  • ATPIR
  • KIAA0956
  • ATPIF
  • ATPIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
metabolite
0.98
transcription factor perturbation
0.97
protein domain
0.92
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.26   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.26   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (84)
1 – 10 of 84
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.959830374
p_ni:  0.040169626
Data Source:  BioPlex
FAM8A1
Tbio
Novelty:  0.08206001
p_int:  0.937603981
p_ni:  0.062396019
Data Source:  BioPlex
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.914044781
p_ni:  0.085955219
Score:  0.319
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.90849359
p_ni:  0.09150641
Data Source:  BioPlex
HIBCH
Tbio
Family:  Enzyme
Novelty:  0.02964018
p_int:  0.879587646
p_ni:  0.120412235
p_wrong:  1.18e-7
Data Source:  BioPlex
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.843602767
p_ni:  0.156397233
p_wrong:  1e-9
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
Score:  0.975
Data Source:  STRINGDB
STOM
Tbio
Novelty:  0.00459891
Score:  0.909
Data Source:  STRINGDB
ATP8A1
Tbio
Family:  Transporter
Novelty:  0.02003643
Score:  0.909
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.908
Data Source:  STRINGDB
Pathways (6)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Ion channel transport
Ion transport by P-type ATPases
Neutrophil degranulation
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
85.3
reticulocyte measurement
2
2
2
60.4
reticulocyte count
2
2
2
50.4
lymphocyte count
1
1
1
46.9
myeloid white cell count
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
85.3
reticulocyte measurement
2
60.4
reticulocyte count
2
50.4
lymphocyte count
1
46.9
myeloid white cell count
1
45.2
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 11B (putative)
VGNC:7957
471016
Macaque
ATPase phospholipid transporting 11B (putative)
708453
Mouse
MGI:1923545
76295
Rat
RGD:1561719
361929
Dog
ATPase phospholipid transporting 11B (putative)
478644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase phospholipid transporting 11B (putative)
Macaque
ATPase phospholipid transporting 11B (putative)
Mouse
Rat
Dog
ATPase phospholipid transporting 11B (putative)
Publication Statistics
PubMed Score 12.26
PubMed score by year
PubTator Score 4.72
PubTator score by year