Tbio CARD8 Caspase recruitment domain-containing protein 8

Protein Summary

Description

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9Y2G2
• B5KVR6
• B7Z496
• B7Z4A2
• E9PEM7
• G3XAM9
• Q6PGP8
• Q96P82

Gene Name

• CARD8

Ensembl ID

• ENST00000391898
• ENSP00000375767
• ENSG00000105483
• ENST00000447740
• ENSP00000391248
• ENST00000519940
• ENSP00000428883
• ENST00000520015
• ENSP00000430747
• ENST00000520153
• ENSP00000428736
• ENST00000520753
• ENSP00000429839
• ENST00000521613
• ENSP00000427858

Symbol

• KIAA0955
• NDPP1
• NDPP
• DACAR
• DAKAR
• NDPP1
• TUCAN
• CARDINAL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.74
microRNA	0.72
disease perturbation	0.68
biological process	0.67
biological term	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.67   (req: < 5)

Gene RIFs: 85   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.67   (req: >= 5)

Gene RIFs: 85   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0