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Tbio
DTX4
E3 ubiquitin-protein ligase DTX4

Protein Summary
Description
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227451
  • ENSP00000227451
  • ENSG00000110042
  • ENST00000532982
  • ENSP00000434055

Symbol
  • KIAA0937
  • RNF155
  • RNF155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.86
PubMedID
0.81
virus perturbation
0.72
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
66.8
sex hormone-binding globulin measurement
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
66.8
sex hormone-binding globulin measurement
1
4.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deltex E3 ubiquitin ligase 4
VGNC:53061
451210
Macaque
deltex E3 ubiquitin ligase 4
700410
Mouse
MGI:2672905
207521
Dog
deltex E3 ubiquitin ligase 4
VGNC:40119
483461
Horse
deltex E3 ubiquitin ligase 4 [Source:HGNC Symbol;Acc:HGNC:29151]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deltex E3 ubiquitin ligase 4
Macaque
deltex E3 ubiquitin ligase 4
Mouse
Dog
deltex E3 ubiquitin ligase 4
Horse
deltex E3 ubiquitin ligase 4 [Source:HGNC Symbol;Acc:HGNC:29151]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2E6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IRF3 mediated activation of type 1 IFN
Reactome
IRF3-mediated induction of type I IFN
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Cytosolic sensors of pathogen-associated DNA
IRF3 mediated activation of type 1 IFN
IRF3-mediated induction of type I IFN
Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.999770191
p_ni:  0.000229809
Data Source:  BioPlex
TULP4
Tbio
Family:  TF
Novelty:  0.05658032
p_int:  0.986333454
p_ni:  0.000341812
p_wrong:  0.013324734
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.983232262
p_ni:  0.016767738
Score:  0.178
Data Source:  BioPlex,STRINGDB
HPCAL1
Tbio
Novelty:  0.04434155
p_int:  0.981539764
p_ni:  0.01841659
p_wrong:  0.000043646
Data Source:  BioPlex
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.972
Data Source:  STRINGDB
NLRP4
Tbio
Novelty:  0.08409252
Score:  0.967
Data Source:  Reactome,STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.952
Data Source:  Reactome,STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
Score:  0.938
Data Source:  STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.929
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.24

PubMed score by year
PubTator Score  7.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer