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Tbio
MAN2B2
Epididymis-specific alpha-mannosidase

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285599
  • ENSP00000285599
  • ENSG00000013288

Symbol
  • KIAA0935
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.9
disease perturbation
0.87
microRNA
0.78
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mannosidase alpha class 2B member 2
710870
Mouse
MGI:1195262
17160
Dog
epididymis-specific alpha-mannosidase
488779
Horse
mannosidase alpha class 2B member 2
VGNC:19911
100056382
Pig
mannosidase alpha class 2B member 2
396847
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mannosidase alpha class 2B member 2
Mouse
Dog
epididymis-specific alpha-mannosidase
Horse
mannosidase alpha class 2B member 2
Pig
mannosidase alpha class 2B member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2E5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Lysosomal oligosaccharide catabolism (R-HSA-8853383)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysosomal oligosaccharide catabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Lysosomal oligosaccharide catabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (36)
1 – 10 of 36
CCDC74A
Tdark
Novelty: 1.52601156
p_int: 0.999999944
p_ni: 5.6e-8
Data Source: BioPlex
SPANXN4
Tdark
Novelty: 1.91062423
p_int: 0.999999897
p_ni: 1.03e-7
Data Source: BioPlex
PRR14
Tbio
Novelty: 0.22401806
p_int: 0.999999844
p_ni: 1.55e-7
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
FUCA2
Tchem
Family: Enzyme
Novelty: 0.02259158
p_int: 0.999986613
p_ni: 0.000013386
p_wrong: 1e-9
Score: 0.314
Data Source: BioPlex,STRINGDB
FBXO6
Tbio
Novelty: 0.02173918
p_int: 0.99939198
p_ni: 0.000608019
Score: 0.169
Data Source: BioPlex,STRINGDB
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.998229583
p_ni: 0.001758804
p_wrong: 0.000011613
Score: 0.61
Data Source: BioPlex,STRINGDB
ODAPH
Tbio
Novelty: 0.20386223
p_int: 0.994910458
p_ni: 0.005082755
p_wrong: 0.000006786
Data Source: BioPlex
SIAE
Tbio
Family: Enzyme
Novelty: 0.01138067
p_int: 0.946311435
p_ni: 0.003519512
p_wrong: 0.050169053
Score: 0.522
Data Source: BioPlex,STRINGDB
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.926682812
p_ni: 0.053812782
p_wrong: 0.019504406
Score: 0.163
Data Source: BioPlex,STRINGDB
MAN2C1
Tbio
Family: Enzyme
Novelty: 0.01159051
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.23

PubMed score by year
PubTator Score  5.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer