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Tbio
AKAP2
A-kinase anchor protein 2

Protein Summary
Description
Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity). The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259318
  • ENSP00000259318
  • ENSG00000241978
  • ENST00000374525
  • ENSP00000363649
  • ENST00000434623
  • ENSP00000404782

Symbol
  • KIAA0920
  • PRKA2
  • MISP2
  • PRKA2
  • AKAP-2
  • AKAPKL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.9
tissue sample
0.73
cell type or tissue
0.62
microRNA
0.62
tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.14   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.14   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (28)
1 – 10 of 28
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999996925
p_wrong:  0.000003075
Score:  0.705
Data Source:  BioPlex,STRINGDB
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
Score:  0.845
Data Source:  STRINGDB
AKAP7
Tbio
Family:  Enzyme
Novelty:  0.04114095
Score:  0.766
Data Source:  STRINGDB
AKAP7
Tbio
Family:  Enzyme
Novelty:  0.04114095
Score:  0.766
Data Source:  STRINGDB
AKAP1
Tbio
Family:  Epigenetic
Novelty:  0.00437217
Score:  0.64
Data Source:  STRINGDB
AKAP10
Tbio
Family:  Enzyme
Novelty:  0.03517248
Score:  0.64
Data Source:  STRINGDB
AKAP11
Tbio
Family:  Enzyme
Novelty:  0.0685826
Score:  0.593
Data Source:  STRINGDB
TUT7
Tbio
Family:  Enzyme
Novelty:  0.06274003
Score:  0.575
Data Source:  STRINGDB
PTBP3
Tbio
Novelty:  0.02001829
Score:  0.535
Data Source:  STRINGDB
TBC1D2
Tbio
Novelty:  0.06055611
Score:  0.531
Data Source:  STRINGDB
Pathways (87)
Items per page:
1 – 5 of 87
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
WikiPathways
G Protein Signaling Pathways
Name
Explore in Pharos
Explore in Source
G Protein Signaling Pathways
G Protein Signaling Pathways
G Protein Signaling Pathways
G Protein Signaling Pathways
G Protein Signaling Pathways
Publication Statistics
PubMed Score 6.14
PubMed score by year
PubTator Score 10.05
PubTator score by year