You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CA5B
Carbonic anhydrase 5B, mitochondrial

Protein Summary
Description
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes carbonic anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A carbonic anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq, Jan 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318636
  • ENSP00000314099
  • ENSG00000169239
  • ENST00000454127
  • ENSP00000417021

Symbol
  • CAVB
  • CA-VB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
virus perturbation
0.85
histone modification site profile
0.82
microRNA
0.75
small molecule perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 312
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (15)
topiramate
Rendered image for topiramate
celecoxib
Rendered image for celecoxib
acetazolamide
Rendered image for acetazolamide
indapamide
Rendered image for indapamide
dorzolamide
Rendered image for dorzolamide
ethoxzolamide
Rendered image for ethoxzolamide
furosemide
Rendered image for furosemide
lacosamide
Rendered image for lacosamide
brinzolamide
Rendered image for brinzolamide
dichlorphenamide
Rendered image for dichlorphenamide
Active Ligands (312)
Protein-Protein Interactions (35)
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.859884806
p_ni:  0.140115193
p_wrong:  1e-9
Score:  0.297
Data Source:  BioPlex,STRINGDB
CYP24A1
Tchem
Family:  Enzyme
Novelty:  0.00107155
Score:  0.836
Data Source:  STRINGDB
UHMK1
Tbio
Family:  Kinase
Novelty:  0.04117277
Score:  0.7
Data Source:  STRINGDB
THRSP
Tbio
Novelty:  0.00938864
Score:  0.676
Data Source:  STRINGDB
BCLAF3
Tdark
Novelty:  1.67603845
Score:  0.66
Data Source:  STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
Score:  0.589
Data Source:  STRINGDB
SLC4A4
Tbio
Family:  Transporter
Novelty:  0.00352439
Score:  0.578
Data Source:  STRINGDB
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
Score:  0.571
Data Source:  STRINGDB
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
Score:  0.57
Data Source:  STRINGDB
TAB3
Tbio
Family:  Enzyme
Novelty:  0.01768638
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 5B
713128
Mouse
MGI:1926249
56078
Rat
RGD:1549783
302669
Dog
carbonic anhydrase 5B
VGNC:38613
100856271
Horse
carbonic anhydrase 5B, mitochondrial
100051095
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 5B
Mouse
Rat
Dog
carbonic anhydrase 5B
Horse
carbonic anhydrase 5B, mitochondrial
Publication Statistics
PubMed Score 57.64
PubMed score by year
PubTator Score 33.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title