Tbio EXOG Nuclease EXOG, mitochondrial

Protein Summary

Description

Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9Y2C4
• A8K242
• B4DVG2
• Q3SXM9
• Q9Y2C8

Gene Name

• EXOG

Ensembl ID

• ENST00000287675
• ENSP00000287675
• ENSG00000157036
• ENST00000422077
• ENSP00000404305

Symbol

• ENDOGL1
• ENDOGL2
• ENGL
• ENGL
• ENGLA
• ENGLB
• ENGL-a
• ENGL-b
• ENDOGL1
• ENDOGL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.64
histone modification site profile	0.62
transcription factor perturbation	0.61
cell line	0.58
tissue sample	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.53   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.53   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0