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Tbio
CNPY2
Protein canopy homolog 2

Protein Summary
Description
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273308
  • ENSP00000273308
  • ENSG00000257727

Symbol
  • MSAP
  • TMEM4
  • ZSIG9
  • MSAP
  • TMEM4
  • ZSIG9
  • HP10390
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.98
transcription factor perturbation
0.97
histone modification site profile
0.9
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
8
9
99.5
5
4
0
1.4
84.7
inflammatory skin disease
1
2
0
1.5
66.6
psoriasis vulgaris
1
1
0
1.4
63.7
lymphocyte percentage of leukocytes
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
99.5
0
1.4
84.7
inflammatory skin disease
0
1.5
66.6
psoriasis vulgaris
0
1.4
63.7
lymphocyte percentage of leukocytes
1
35
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2B0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (43)
1 – 10 of 43
KIF22
Tbio
Novelty:  0.0109594
p_int:  0.999999535
p_ni:  4.65e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.99999565
p_ni:  0.000004348
p_wrong:  2e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.99991428
p_ni:  0.000085717
p_wrong:  2e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
CTC1
Tbio
Novelty:  0.01298038
p_int:  0.99991322
p_ni:  0.00008678
Score:  0.588
Data Source:  BioPlex,STRINGDB
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
p_int:  0.99979902
p_ni:  0.00020098
Score:  0.216
Data Source:  BioPlex,STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.998486233
p_ni:  0.000001456
p_wrong:  0.001512311
Data Source:  BioPlex
COL2A1
Tbio
Novelty:  0.0011102
p_int:  0.996517414
p_ni:  0.003378632
p_wrong:  0.000103953
Score:  0.19
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.981895996
p_ni:  0.018094659
p_wrong:  0.000009345
Score:  0.213
Data Source:  BioPlex,STRINGDB
GNB1L
Tbio
Novelty:  0.03388865
p_int:  0.977611578
p_ni:  0.022388422
Score:  0.19
Data Source:  BioPlex,STRINGDB
WDR45B
Tbio
Novelty:  0.22407227
p_int:  0.90053283
p_ni:  0.099467169
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.95

PubMed score by year
PubTator Score  18.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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