You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
B3GNT3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

Protein Summary
Description
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191). This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318683
  • ENSP00000321874
  • ENSG00000179913
  • ENST00000595387
  • ENSP00000472638

Symbol
  • B3GALT8
  • TMEM3
  • TMEM3
  • B3GN-T3
  • B3GNT-3
  • HP10328
  • B3GAL-T8
  • beta3Gn-T3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
cellular component
0.61
small molecule perturbation
0.6
pathway
0.56
PubMedID
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.46   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.46   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
83.1
4
3
4
76.7
cancer antigen 19.9 measurement
1
1
1
57.8
basophil count
1
1
1
53.7
2
1
0
1.1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
83.1
4
76.7
cancer antigen 19.9 measurement
1
57.8
basophil count
1
53.7
0
1.1
53.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
455847
Macaque
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
719221
Mouse
MGI:2152535
72297
Rat
RGD:1305151
290638
Dog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
VGNC:38342
484831
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Macaque
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Mouse
Rat
Dog
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y2A9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (78)
1 – 10 of 78
CD19
Tclin
Novelty:  0.0001816
p_int:  0.998629257
p_ni:  0.000136099
p_wrong:  0.001234644
Score:  0.218
Data Source:  BioPlex,STRINGDB
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.992797187
p_ni:  0.005555278
p_wrong:  0.001647535
Score:  0.522
Data Source:  BioPlex,STRINGDB
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.986636824
p_ni:  0.01336304
p_wrong:  1.36e-7
Score:  0.395
Data Source:  BioPlex,STRINGDB
HS6ST1
Tbio
Family:  Enzyme
Novelty:  0.01352454
p_int:  0.973083754
p_ni:  0.020396237
p_wrong:  0.006520008
Score:  0.352
Data Source:  BioPlex,STRINGDB
C6orf120
Tdark
Novelty:  0.90888293
p_int:  0.966090891
p_ni:  0.031318896
p_wrong:  0.002590212
Score:  0.189
Data Source:  BioPlex,STRINGDB
PGRMC1
Tchem
Novelty:  0.00364386
p_int:  0.954800635
p_ni:  0.045199365
Score:  0.345
Data Source:  BioPlex,STRINGDB
GALNT12
Tbio
Family:  Enzyme
Novelty:  0.085131
p_int:  0.903975646
p_ni:  0.080007046
p_wrong:  0.016017308
Score:  0.27
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.863600889
p_ni:  0.136399111
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.852235982
p_ni:  0.145822139
p_wrong:  0.001941878
Data Source:  BioPlex
MBOAT7
Tbio
Family:  Enzyme
Novelty:  0.01861411
p_int:  0.795197736
p_ni:  0.204802205
p_wrong:  5.9e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  18.46

PubMed score by year
PubTator Score  6.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: