Tbio NCKAP1 Nck-associated protein 1

Protein Summary

Description

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

Uniprot Accession IDs

• Q9Y2A7
• O60329
• Q53QN5
• Q53S94
• Q53Y35
• NAP 1

Gene Name

• NCKAP1

Ensembl ID

• ENST00000360982
• ENSP00000354251
• ENSG00000061676
• ENST00000361354
• ENSP00000355348

Symbol

• HEM2
• KIAA0587
• NAP1
• HEM2
• NAP1
• NAP125
• p125Nap1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
gene perturbation	0.95
biological process	0.9
transcription factor perturbation	0.84
interacting protein	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.02   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.02   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0