NCKAP1
Nck-associated protein 1
Protein Summary
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
- ENST00000360982
- ENSP00000354251
- ENSG00000061676
- ENST00000361354
- ENSP00000355348
- HEM2
- KIAA0587
- NAP1
- HEM2
- NAP1
- NAP125
- p125Nap1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
gene perturbation | 0.95 | ||
biological process | 0.9 | ||
transcription factor perturbation | 0.84 | ||
interacting protein | 0.83 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.32 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.32 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (19)
Reactome (11)
KEGG (1)
PathwayCommons (5)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate WASPs and WAVEs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Immune System | ||||
Innate Immune System | ||||
RHO GTPase Effectors | ||||
RHO GTPases Activate WASPs and WAVEs | ||||
Gene Ontology Terms (23)
Functions (1)
Components (9)
Processes (13)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (137)
1 – 10 of 137
NHSL1
Novelty: 0.28557146
p_int: 0.999999994
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.299
Data Source: BioPlex,STRINGDB
WASF1
Novelty: 0.00977488
p_int: 0.999999992
p_ni: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI1
Novelty: 0.00796638
p_int: 0.999999941
p_ni: 6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
ABI2
Novelty: 0.02324355
p_int: 0.999999908
p_ni: 9.2e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
KIAA1522
Novelty: 0.15028395
p_int: 0.999999648
p_ni: 3.52e-7
Data Source: BioPlex
WASF2
Novelty: 0.00968798
p_int: 0.999999203
p_ni: 7.97e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CYFIP2
Novelty: 0.01910939
p_int: 0.999998888
p_ni: 0.000001112
Score: 0.999
Data Source: BioPlex,STRINGDB
BRK1
Novelty: 0.02289534
p_int: 0.999998212
p_ni: 0.000001781
p_wrong: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
AMZ1
Family: Enzyme
Novelty: 0.246305
p_int: 0.999997996
p_ni: 0.000002004
Score: 0.329
Data Source: BioPlex,STRINGDB
NCK2
Novelty: 0.02220251
p_int: 0.999988022
p_ni: 0.000011978
Score: 0.667
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 29.32
PubMed score by year
PubTator Score 11.56
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword