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Tbio
NCKAP1
Nck-associated protein 1

Protein Summary
Description
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360982
  • ENSP00000354251
  • ENSG00000061676
  • ENST00000361354
  • ENSP00000355348

Symbol
  • HEM2
  • KIAA0587
  • NAP1
  • HEM2
  • NAP1
  • NAP125
  • p125Nap1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
gene perturbation
0.95
biological process
0.9
transcription factor perturbation
0.84
interacting protein
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.32   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (137)
1 – 10 of 137
NHSL1
Tdark
Novelty: 0.28557146
p_int: 0.999999994
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.299
Data Source: BioPlex,STRINGDB
WASF1
Tbio
Novelty: 0.00977488
p_int: 0.999999992
p_ni: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI1
Tbio
Novelty: 0.00796638
p_int: 0.999999941
p_ni: 6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999999908
p_ni: 9.2e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
KIAA1522
Tdark
Novelty: 0.15028395
p_int: 0.999999648
p_ni: 3.52e-7
Data Source: BioPlex
WASF2
Tbio
Novelty: 0.00968798
p_int: 0.999999203
p_ni: 7.97e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CYFIP2
Tbio
Novelty: 0.01910939
p_int: 0.999998888
p_ni: 0.000001112
Score: 0.999
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999998212
p_ni: 0.000001781
p_wrong: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.999997996
p_ni: 0.000002004
Score: 0.329
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999988022
p_ni: 0.000011978
Score: 0.667
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  29.32

PubMed score by year
PubTator Score  11.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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