Tbio NCKAP1 Nck-associated protein 1

Protein Summary

Description

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

Uniprot Accession IDs

• Q9Y2A7
• O60329
• Q53QN5
• Q53S94
• Q53Y35
• NAP 1

Gene Name

• NCKAP1

Ensembl ID

• ENST00000360982
• ENSP00000354251
• ENSG00000061676
• ENST00000361354
• ENSP00000355348

Symbol

• HEM2
• KIAA0587
• NAP1
• HEM2
• NAP1
• NAP125
• p125Nap1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
gene perturbation	0.95
biological process	0.9
transcription factor perturbation	0.84
interacting protein	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.95   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.95   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (137)

Explore Interacting Targets

1 – 10 of 137

• See Interactions on String-DB

NHSL1

Tdark

Novelty:  0.28557146

p_int:  0.999999994

p_ni:  6e-9

p_wrong:  1e-9

Score:  0.299

Data Source:  BioPlex,STRINGDB

WASF1

Tbio

Novelty:  0.00977488

p_int:  0.999999992

p_ni:  8e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

ABI1

Tbio

Novelty:  0.00796638

p_int:  0.999999941

p_ni:  6e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

ABI2

Tbio

Novelty:  0.02324355

p_int:  0.999999908

p_ni:  9.2e-8

Score:  0.995

Data Source:  BioPlex,STRINGDB

KIAA1522

Tdark

Novelty:  0.15028395

p_int:  0.999999648

p_ni:  3.52e-7

Data Source:  BioPlex

WASF2

Tbio

Novelty:  0.00968798

p_int:  0.999999203

p_ni:  7.97e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

CYFIP2

Tbio

Novelty:  0.01910939

p_int:  0.999998888

p_ni:  0.000001112

Score:  0.999

Data Source:  BioPlex,STRINGDB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.999998212

p_ni:  0.000001781

p_wrong:  6e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

AMZ1

Tdark

Family:  Enzyme

Novelty:  0.246305

p_int:  0.999997996

p_ni:  0.000002004

Score:  0.329

Data Source:  BioPlex,STRINGDB

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.999988022

p_ni:  0.000011978

Score:  0.667

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (19)

Reactome (11)

KEGG (1)

PathwayCommons (5)

WikiPathways (2)

Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

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1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fcgamma receptor (FCGR) dependent phagocytosis	163 targets	R-HSA-2029480
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	RHO GTPase Effectors	273 targets	R-HSA-195258
Reactome	RHO GTPases Activate WASPs and WAVEs	36 targets	R-HSA-5663213

Name	Explore in Pharos	Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis	163 targets	R-HSA-2029480
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
RHO GTPase Effectors	273 targets	R-HSA-195258
RHO GTPases Activate WASPs and WAVEs	36 targets	R-HSA-5663213

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (1)

Components (9)

Processes (13)

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1 – 1 of 1

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	1	3		70.9
self reported educational attainment	EFO_0004784	1	1	1		5.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		70.9
self reported educational attainment	EFO_0004784	1		5.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell membrane
Cell projection
Complete proteome
Host-virus interaction
Membrane
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
heel bone mineral density
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
digestive/alimentary phenotype
embryo phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NCK associated protein 1	VGNC:2059	459801
Macaque	NCK associated protein 1		711124
Mouse	NCK-associated protein 1	MGI:1355333	50884
Rat	NCK-associated protein 1	RGD:61939	58823
Dog	NCK associated protein 1	VGNC:43653	478828

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NCK associated protein 1
Macaque	NCK associated protein 1
Mouse	NCK-associated protein 1
Rat	NCK-associated protein 1
Dog	NCK associated protein 1

Publication Statistics

PubMed Score 29.95

PubMed score by year

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PubTator Score 11.56

PubTator score by year

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Related Publications

Text Mined References (33)

GeneRif Annotations (5)

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10

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PMID	Year	Title