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Tbio
NCKAP1
Nck-associated protein 1

Protein Summary
Description
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360982
  • ENSP00000354251
  • ENSG00000061676
  • ENST00000361354
  • ENSP00000355348

Symbol
  • HEM2
  • KIAA0587
  • NAP1
  • HEM2
  • NAP1
  • NAP125
  • p125Nap1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
gene perturbation
0.95
biological process
0.9
transcription factor perturbation
0.84
interacting protein
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.32   (req: < 5)
View Publications
Gene RIFs: 5   (req: <= 3)
View Gene RIFs
Antibodies: 183   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NCK associated protein 1
VGNC:2059
459801
Macaque
NCK associated protein 1
711124
Mouse
NCK-associated protein 1
MGI:1355333
50884
Rat
NCK-associated protein 1
RGD:61939
58823
Dog
NCK associated protein 1
VGNC:43653
478828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NCK associated protein 1
Macaque
NCK associated protein 1
Mouse
NCK-associated protein 1
Rat
NCK-associated protein 1
Dog
NCK associated protein 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2A7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
163 targets
R-HSA-2029480
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Innate Immune System
1188 targets
R-HSA-168249
Reactome
RHO GTPase Effectors
273 targets
R-HSA-195258
Reactome
RHO GTPases Activate WASPs and WAVEs
36 targets
R-HSA-5663213
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
163 targets
R-HSA-2029480
Immune System
2246 targets
R-HSA-168256
Innate Immune System
1188 targets
R-HSA-168249
RHO GTPase Effectors
273 targets
R-HSA-195258
RHO GTPases Activate WASPs and WAVEs
36 targets
R-HSA-5663213
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
protein-containing complex binding
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (137)
1 – 10 of 137
NHSL1
Tdark
Novelty: 0.28557146
p_int: 0.999999994
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.299
Data Source: BioPlex,STRINGDB
WASF1
Tbio
Novelty: 0.00977488
p_int: 0.999999992
p_ni: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI1
Tbio
Novelty: 0.00796638
p_int: 0.999999941
p_ni: 6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999999908
p_ni: 9.2e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
KIAA1522
Tdark
Novelty: 0.15028395
p_int: 0.999999648
p_ni: 3.52e-7
Data Source: BioPlex
WASF2
Tbio
Novelty: 0.00968798
p_int: 0.999999203
p_ni: 7.97e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CYFIP2
Tbio
Novelty: 0.01910939
p_int: 0.999998888
p_ni: 0.000001112
Score: 0.999
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999998212
p_ni: 0.000001781
p_wrong: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.999997996
p_ni: 0.000002004
Score: 0.329
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999988022
p_ni: 0.000011978
Score: 0.667
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  29.32

PubMed score by year
PubTator Score  11.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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