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Tbio
BTRC
F-box/WD repeat-containing protein 1A

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370187
  • ENSP00000359206
  • ENSG00000166167
  • ENST00000408038
  • ENSP00000385339

Symbol
  • BTRCP
  • FBW1A
  • FBXW1A
  • FWD1
  • FBW1A
  • FBXW1
  • bTrCP
  • FBXW1A
  • bTrCP1
  • betaTrCP
  • BETA-TRCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
biological process
0.97
hub protein
0.92
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.05   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.05   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (112)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 69
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
Gene Ontology Terms (43)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (630)
1 – 10 of 630
FBXW11
Tbio
Novelty: 0.14703388
p_int: 1
Score: 0.966
Data Source: BioPlex,STRINGDB
HIVEP1
Tbio
Family: TF
Novelty: 0.03959964
p_int: 1
Score: 0.56
Data Source: BioPlex,STRINGDB
TFAP4
Tbio
Family: TF
Novelty: 0.03921108
p_int: 1
Score: 0.371
Data Source: BioPlex,STRINGDB
MLPH
Tbio
Novelty: 0.02388794
p_int: 0.999999999
Score: 0.188
Data Source: BioPlex,STRINGDB
HIVEP2
Tbio
Family: TF
Novelty: 0.03174474
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.566
Data Source: BioPlex,STRINGDB
FBXO5
Tbio
Novelty: 0.01799521
p_int: 0.999999995
p_ni: 5e-9
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
CDC25B
Tchem
Family: Enzyme
Novelty: 0.0044301
p_int: 0.999999992
p_ni: 8e-9
Score: 0.678
Data Source: BioPlex,STRINGDB
EGFLAM
Tbio
Novelty: 0.00504701
p_int: 0.99999998
p_ni: 1.4e-8
p_wrong: 6e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
USP47
Tchem
Family: Enzyme
Novelty: 0.12618297
p_int: 0.999999834
p_ni: 1.66e-7
Score: 0.962
Data Source: BioPlex,STRINGDB
USP37
Tbio
Family: Enzyme
Novelty: 0.06955946
p_int: 0.999999612
p_ni: 8.5e-8
p_wrong: 3.03e-7
Score: 0.473
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  223.05

PubMed score by year
PubTator Score  175.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKII
1-70
PEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKY
70-140
FEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAEL
140-210
VCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIE
210-280
TIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ
280-350
YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR
350-420
VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRL
420-490
WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFR
490-560
LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR
560-605
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR