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Tbio
TRAPPC4
Trafficking protein particle complex subunit 4

Protein Summary
Description
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434101
  • ENSP00000405033
  • ENSG00000196655
  • ENST00000533632
  • ENSP00000436005
  • ENST00000629243
  • ENSP00000487467
  • ENSG00000280495
  • ENST00000629713
  • ENSP00000486496

Symbol
  • SBDN
  • SBDN
  • TRS23
  • PTD009
  • CGI-104
  • HSPC172
  • SYNBINDIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.88
disease perturbation
0.87
interacting protein
0.86
transcription factor binding site profile
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.99   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.99   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.999999539
p_ni:  4.6e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.999999322
p_ni:  6.78e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999998412
p_ni:  0.000001587
Score:  0.997
Data Source:  BioPlex,STRINGDB
BCL2L14
Tbio
Novelty:  0.03980069
p_int:  0.999871681
p_ni:  0.000128319
Score:  0.763
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999834055
p_ni:  0.000165945
Score:  0.991
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.999325478
p_ni:  0.00067452
p_wrong:  1e-9
Score:  0.742
Data Source:  BioPlex,STRINGDB
KANK4
Tdark
Novelty:  0.22871735
p_int:  0.999176347
p_ni:  0.000823653
Score:  0.746
Data Source:  BioPlex,STRINGDB
TBC1D14
Tbio
Novelty:  0.25089884
p_int:  0.998615816
p_ni:  0.001384184
Score:  0.857
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.99636072
p_ni:  0.00363928
Score:  0.517
Data Source:  BioPlex,STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
p_int:  0.993039326
p_ni:  0.006960669
p_wrong:  5e-9
Score:  0.671
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Extracellular matrix organization
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Extracellular matrix organization
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
86.7
body mass index
3
3
3
79.5
waist-hip ratio
2
2
2
75
high density lipoprotein cholesterol measurement
1
1
1
73.9
apolipoprotein A 1 measurement
1
1
1
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
86.7
body mass index
3
79.5
waist-hip ratio
2
75
high density lipoprotein cholesterol measurement
1
73.9
apolipoprotein A 1 measurement
1
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 4
VGNC:13315
451598
Macaque
trafficking protein particle complex 4
702469
Mouse
MGI:1926211
60409
Rat
RGD:1302991
367073
Dog
trafficking protein particle complex 4
VGNC:47783
479411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 4
Macaque
trafficking protein particle complex 4
Mouse
Rat
Dog
trafficking protein particle complex 4
Publication Statistics
PubMed Score 19.99
PubMed score by year
PubTator Score 5.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title