You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DRG1
Developmentally-regulated GTP-binding protein 1

Protein Summary
Description
Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331457
  • ENSP00000329715
  • ENSG00000185721

Symbol
  • NEDD3
  • NEDD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
disease perturbation
0.99
kinase perturbation
0.96
histone modification site profile
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.56   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
1
3
76.2
myeloid white cell count
1
1
1
72.1
sum of basophil and neutrophil counts
1
1
1
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
76.2
myeloid white cell count
1
72.1
sum of basophil and neutrophil counts
1
13.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
developmentally regulated GTP binding protein 1
VGNC:5255
107970225
Macaque
developmentally regulated GTP binding protein 1
716791
Mouse
MGI:1343297
13494
Rat
RGD:1304993
305470
Dog
developmentally regulated GTP binding protein 1
VGNC:40097
477543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
developmentally regulated GTP binding protein 1
Macaque
developmentally regulated GTP binding protein 1
Mouse
Rat
Dog
developmentally regulated GTP binding protein 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (141)
1 – 10 of 141
LRRC41
Tbio
Novelty: 0.12601472
p_int: 0.999999683
p_ni: 3.17e-7
Score: 0.332
Data Source: BioPlex,STRINGDB
NTMT1
Tbio
Family: Enzyme
Novelty: 0.06322967
p_int: 0.999994988
p_ni: 0.000004994
p_wrong: 1.7e-8
Score: 0.537
Data Source: BioPlex,STRINGDB
ZC3H15
Tbio
Novelty: 0.15630592
p_int: 0.999631053
p_ni: 0.000368947
Score: 0.997
Data Source: BioPlex,STRINGDB
OSCP1
Tbio
Novelty: 0.05361924
p_int: 0.993319347
p_ni: 0.000246071
p_wrong: 0.006434582
Score: 0.252
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
RWDD1
Tdark
Novelty: 0.14946142
Score: 0.928
Data Source: STRINGDB
CAND2
Tbio
Novelty: 0.08940552
Score: 0.885
Data Source: STRINGDB
ABCE1
Tbio
Family: Transporter
Novelty: 0.00529126
Score: 0.882
Data Source: STRINGDB
WDR12
Tbio
Novelty: 0.03409059
Score: 0.855
Data Source: STRINGDB
NIFK
Tbio
Novelty: 0.01221562
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.56

PubMed score by year
PubTator Score  34.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer