Protein Summary
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
- ENST00000229595
- ENSP00000229595
- ENSG00000111875
- CIA
- CGI-98
- HSPC146
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.88 | ||
disease perturbation | 0.79 | ||
biological process | 0.75 | ||
histone modification site profile | 0.74 | ||
transcription factor binding site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.69 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 386 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.69 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 386 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (227)
C15orf41
Novelty: 0.11812699
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
CDAN1
Novelty: 0.00610604
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.663
Data Source: BioPlex,STRINGDB
UBN2
Novelty: 0.09777456
p_int: 0.999999982
p_ni: 1.7e-8
p_wrong: 1e-9
Score: 0.578
Data Source: BioPlex,STRINGDB
UBN1
Novelty: 0.01703683
p_int: 0.999999969
p_ni: 1.5e-8
p_wrong: 1.7e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
PAN3
Family: Kinase
Novelty: 3.36673347
p_int: 0.999999969
p_ni: 3e-8
p_wrong: 1e-9
Score: 0.247
Data Source: BioPlex,STRINGDB
CABIN1
Novelty: 0.02528794
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
HIRA
Novelty: 0.01362595
p_int: 0.999999945
p_ni: 5.1e-8
p_wrong: 4e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
TLK1
Family: Kinase
Novelty: 0.0342719
p_int: 0.999999774
p_ni: 2.26e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
TLK2
Family: Kinase
Novelty: 0.07082609
p_int: 0.999999664
p_ni: 3.36e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
PAN2
Family: Enzyme
Novelty: 0.1195117
p_int: 0.999998742
p_ni: 1.08e-7
p_wrong: 0.00000115
Score: 0.58
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (5)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | DNA Damage/Telomere Stress Induced Senescence | ||||
Reactome | Formation of Senescence-Associated Heterochromatin Foci (SAHF) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
DNA Damage/Telomere Stress Induced Senescence | ||||
Formation of Senescence-Associated Heterochromatin Foci (SAHF) | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 5 | 5 | 98 | |||||
mean platelet volume | 2 | 1 | 2 | 76.1 | |||||
self reported educational attainment | 2 | 2 | 2 | 73.4 | |||||
mathematical ability | 2 | 2 | 2 | 69.6 | |||||
dehydroepiandrosterone sulphate measurement | 1 | 1 | 2 | 51.7 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 98 | |||||
mean platelet volume | 2 | 76.1 | |||||
self reported educational attainment | 2 | 73.4 | |||||
mathematical ability | 2 | 69.6 | |||||
dehydroepiandrosterone sulphate measurement | 2 | 51.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | anti-silencing function 1A histone chaperone | VGNC:12586 | 100614128 | |||||
Macaque | anti-silencing function 1A histone chaperone | 714761 | ||||||
Mouse | MGI:3782074 | 100042554 | ||||||
Rat | RGD:1311941 | 294408 | ||||||
Dog | anti-silencing function 1A histone chaperone | VGNC:50621 | 476273 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | anti-silencing function 1A histone chaperone | |||||
Macaque | anti-silencing function 1A histone chaperone | |||||
Mouse | ||||||
Rat | ||||||
Dog | anti-silencing function 1A histone chaperone | |||||
Publication Statistics
PubMed Score 40.69
PubMed score by year
PubTator Score 34.84
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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