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Tchem
ASF1A
Histone chaperone ASF1A

Protein Summary
Description
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229595
  • ENSP00000229595
  • ENSG00000111875

Symbol
  • CIA
  • CGI-98
  • HSPC146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
disease perturbation
0.79
biological process
0.75
histone modification site profile
0.74
transcription factor binding site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.69   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 386   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.69   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL199405
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
77.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anti-silencing function 1A histone chaperone
VGNC:12586
100614128
Macaque
anti-silencing function 1A histone chaperone
714761
Mouse
MGI:3782074
100042554
Rat
RGD:1311941
294408
Dog
anti-silencing function 1A histone chaperone
VGNC:50621
476273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anti-silencing function 1A histone chaperone
Macaque
anti-silencing function 1A histone chaperone
Mouse
Rat
Dog
anti-silencing function 1A histone chaperone
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y294-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
DNA Damage/Telomere Stress Induced Senescence
Reactome
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (227)
1 – 10 of 227
C15orf41
Tbio
Novelty: 0.11812699
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
CDAN1
Tbio
Novelty: 0.00610604
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.663
Data Source: BioPlex,STRINGDB
UBN2
Tbio
Novelty: 0.09777456
p_int: 0.999999982
p_ni: 1.7e-8
p_wrong: 1e-9
Score: 0.578
Data Source: BioPlex,STRINGDB
UBN1
Tbio
Novelty: 0.01703683
p_int: 0.999999969
p_ni: 1.5e-8
p_wrong: 1.7e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
PAN3
Tdark
Family: Kinase
Novelty: 3.36673347
p_int: 0.999999969
p_ni: 3e-8
p_wrong: 1e-9
Score: 0.247
Data Source: BioPlex,STRINGDB
CABIN1
Tbio
Novelty: 0.02528794
p_int: 0.999999952
p_ni: 4.8e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
HIRA
Tbio
Novelty: 0.01362595
p_int: 0.999999945
p_ni: 5.1e-8
p_wrong: 4e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
TLK1
Tchem
Family: Kinase
Novelty: 0.0342719
p_int: 0.999999774
p_ni: 2.26e-7
Score: 0.98
Data Source: BioPlex,STRINGDB
TLK2
Tchem
Family: Kinase
Novelty: 0.07082609
p_int: 0.999999664
p_ni: 3.36e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
PAN2
Tbio
Family: Enzyme
Novelty: 0.1195117
p_int: 0.999998742
p_ni: 1.08e-7
p_wrong: 0.00000115
Score: 0.58
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  40.69

PubMed score by year
PubTator Score  34.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer