Tchem ASF1A Histone chaperone ASF1A

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Histone Chaperone Asf1a

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Histone Chaperone Asf1a

Protein Summary

Description

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y294
• Q6IA08
• Q9P014

Gene Name

• ASF1A

Ensembl ID

• ENST00000229595
• ENSP00000229595
• ENSG00000111875

Symbol

• CIA
• CGI-98
• HSPC146

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.88
disease perturbation	0.79
biological process	0.75
histone modification site profile	0.74
transcription factor binding site profile	0.73

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.69   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 386   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.69   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL199405

ASF1ATchem

IC50 : 6.22

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2	1	2		77.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	2		77.1

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	anti-silencing function 1A histone chaperone	VGNC:12586	100614128
Macaque	anti-silencing function 1A histone chaperone		714761
Mouse	predicted gene 3902	MGI:3782074	100042554
Rat	anti-silencing function 1A histone chaperone	RGD:1311941	294408
Dog	anti-silencing function 1A histone chaperone	VGNC:50621	476273

Species	Name	OMA	EggNOG	Inparanoid
Chimp	anti-silencing function 1A histone chaperone
Macaque	anti-silencing function 1A histone chaperone
Mouse	predicted gene 3902
Rat	anti-silencing function 1A histone chaperone
Dog	anti-silencing function 1A histone chaperone

Protein Structure (6 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y294-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (8)

Reactome (5)

WikiPathways (3)

Cellular Senescence (R-HSA-2559583)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	DNA Damage/Telomere Stress Induced Senescence	61 targets	R-HSA-2559586
Reactome	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	17 targets	R-HSA-2559584

Name	Explore in Pharos	Explore in Source
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
DNA Damage/Telomere Stress Induced Senescence	61 targets	R-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	17 targets	R-HSA-2559584

Gene Ontology Terms (13)

Functions (2)

Components (4)

Processes (7)

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1 – 2 of 2

GO Term	Evidence	Assigned by
histone binding	Inferred from Direct Assay (IDA)	MGI
chromatin binding	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (227)

Explore Interacting Targets

1 – 10 of 227

• See Interactions on String-DB

C15orf41

Tbio

Novelty: 0.11812699

p_int: 0.999999996

p_ni: 1e-9

p_wrong: 3e-9

Score: 0.228

Data Source: BioPlex,STRINGDB

CDAN1

Tbio

Novelty: 0.00610604

p_int: 0.999999993

p_ni: 6e-9

p_wrong: 1e-9

Score: 0.663

Data Source: BioPlex,STRINGDB

UBN2

Tbio

Novelty: 0.09777456

p_int: 0.999999982

p_ni: 1.7e-8

p_wrong: 1e-9

Score: 0.578

Data Source: BioPlex,STRINGDB

UBN1

Tbio

Novelty: 0.01703683

p_int: 0.999999969

p_ni: 1.5e-8

p_wrong: 1.7e-8

Score: 0.981

Data Source: BioPlex,Reactome,STRINGDB

PAN3

Tdark

Family: Kinase

Novelty: 3.36673347

p_int: 0.999999969

p_ni: 3e-8

p_wrong: 1e-9

Score: 0.247

Data Source: BioPlex,STRINGDB

CABIN1

Tbio

Novelty: 0.02528794

p_int: 0.999999952

p_ni: 4.8e-8

Score: 0.982

Data Source: BioPlex,Reactome,STRINGDB

HIRA

Tbio

Novelty: 0.01362595

p_int: 0.999999945

p_ni: 5.1e-8

p_wrong: 4e-9

Score: 0.995

Data Source: BioPlex,Reactome,STRINGDB

TLK1

Tchem

Family: Kinase

Novelty: 0.0342719

p_int: 0.999999774

p_ni: 2.26e-7

Score: 0.98

Data Source: BioPlex,STRINGDB

TLK2

Tchem

Family: Kinase

Novelty: 0.07082609

p_int: 0.999999664

p_ni: 3.36e-7

Score: 0.968

Data Source: BioPlex,STRINGDB

PAN2

Tbio

Family: Enzyme

Novelty: 0.1195117

p_int: 0.999998742

p_ni: 1.08e-7

p_wrong: 0.00000115

Score: 0.58

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  40.69

PubMed score by year

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PubTator Score  34.84

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Chaperone
Chromatin regulator
Complete proteome
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

mean platelet volume

MGI Phenotype Find Similar Targets

embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype