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Tbio
SLC5A6
Sodium-dependent multivitamin transporter

Protein Summary
Description
Transports pantothenate, biotin and lipoate in the presence of sodium.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310574
  • ENSP00000310208
  • ENSG00000138074
  • ENST00000408041
  • ENSP00000384853

Symbol
  • SMVT
  • SMVT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
pathway
0.85
disease perturbation
0.83
histone modification site profile
0.83
transcription factor binding site profile
0.78


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.33   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.33   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
40.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
40.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 6
VGNC:7712
459096
Macaque
solute carrier family 5 member 6
699074
Mouse
MGI:2660847
330064
Rat
RGD:69648
170551
Dog
solute carrier family 5 member 6
VGNC:46449
475698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 6
Macaque
solute carrier family 5 member 6
Mouse
Rat
Dog
solute carrier family 5 member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y289-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (37)
Biotin transport and metabolism (R-HSA-196780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biotin transport and metabolism
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Biotin transport and metabolism
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
SLC-mediated transmembrane transport
Protein-Protein Interactions (40)
1 – 10 of 40
PDZK1P1
Tdark
p_int: 0.996398268
p_ni: 0.003601732
Data Source: BioPlex
PDZD11
Tbio
Novelty: 0.09750858
Score: 0.928
Data Source: Reactome,STRINGDB
HLCS
Tchem
Family: Enzyme
Novelty: 0.01597449
Score: 0.686
Data Source: STRINGDB
SLC16A5
Tdark
Family: Transporter
Novelty: 0.08427299
Score: 0.652
Data Source: STRINGDB
SLC17A1
Tbio
Family: Transporter
Novelty: 0.0127372
Score: 0.627
Data Source: STRINGDB
BTD
Tbio
Family: Enzyme
Novelty: 0.01638573
Score: 0.616
Data Source: STRINGDB
TBXT
Tbio
Family: TF
Novelty: 0.00660122
Score: 0.587
Data Source: STRINGDB
SLC37A1
Tbio
Family: Transporter
Novelty: 0.11329328
Score: 0.574
Data Source: STRINGDB
SLC16A9
Tbio
Family: Transporter
Novelty: 0.06564904
Score: 0.558
Data Source: STRINGDB
SLC22A12
Tclin
Family: Transporter
Novelty: 0.00318081
Score: 0.55
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.33

PubMed score by year
PubTator Score  51.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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