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Tbio
ITM2B
Integral membrane protein 2B

Protein Summary
Description
Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites. Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378549
  • ENSP00000367811
  • ENSG00000136156
  • ENST00000378565
  • ENSP00000367828
  • ENST00000647800
  • ENSP00000497221

Symbol
  • BRI
  • BRI2
  • BRI
  • FBD
  • ABRI
  • BRI2
  • E25B
  • E3-16
  • RDGCA
  • imBRI2
  • BRICD2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
0.88
molecular function
0.84
PubMedID
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.24   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.24   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
2
2
75.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
75.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integral membrane protein 2B
VGNC:5071
452714
Macaque
integral membrane protein 2B
709896
Mouse
MGI:1309517
16432
Rat
RGD:620727
290364
Dog
integral membrane protein 2B
VGNC:42150
476916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integral membrane protein 2B
Macaque
integral membrane protein 2B
Mouse
Rat
Dog
integral membrane protein 2B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y287-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (73)
1 – 10 of 73
SEMA6A
Tbio
Novelty: 0.00624456
p_int: 0.999685732
p_ni: 0.000314256
p_wrong: 1.2e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
TMEM219
Tdark
Novelty: 0.33292987
p_int: 0.996182301
p_ni: 0.003817699
Score: 0.163
Data Source: BioPlex,STRINGDB
DCBLD2
Tbio
Novelty: 0.06514947
p_int: 0.984863949
p_ni: 0.015134877
p_wrong: 0.000001174
Score: 0.189
Data Source: BioPlex,STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.984262696
p_ni: 0.015737304
Score: 0.216
Data Source: BioPlex,STRINGDB
TMEM59L
Tbio
Novelty: 0.22745646
p_int: 0.975425599
p_ni: 0.018628331
p_wrong: 0.005946069
Score: 0.18
Data Source: BioPlex,STRINGDB
BTN2A2
Tdark
Novelty: 0.46565474
p_int: 0.97457162
p_ni: 0.025428345
p_wrong: 3.5e-8
Data Source: BioPlex
TGFBR3
Tbio
Novelty: 0.0077307
p_int: 0.921493745
p_ni: 0.078493642
p_wrong: 0.000012613
Score: 0.185
Data Source: BioPlex,STRINGDB
AMIGO1
Tbio
Novelty: 0.00864791
p_int: 0.917176377
p_ni: 0.082370842
p_wrong: 0.00045278
Data Source: BioPlex
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.909702881
p_ni: 0.090297119
Data Source: BioPlex
CHST12
Tbio
Family: Enzyme
Novelty: 0.04560641
p_int: 0.890701067
p_ni: 0.109298933
Score: 0.193
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  117.24

PubMed score by year
PubTator Score  115.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer