You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SIGLEC7
Sialic acid-binding Ig-like lectin 7

Protein Classes
Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305628
  • ENSP00000306757
  • ENSG00000168995
  • ENST00000317643
  • ENSP00000323328
  • ENST00000536156
  • ENSP00000437609
  • ENST00000600577
  • ENSP00000472529

Symbol
  • AIRM1
  • p75
  • QA79
  • AIRM1
  • CD328
  • CDw328
  • D-siglec
  • SIGLEC-7
  • SIGLECP2
  • SIGLEC19P
  • p75/AIRM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.65
kinase perturbation
0.54
small molecule perturbation
0.53
disease perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 749   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.41   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 749   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (65)
1 – 10 of 65
IFT74
Tbio
Novelty: 0.07195266
p_int: 0.999998414
p_ni: 0.000001116
p_wrong: 4.7e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
WDR89
Tdark
Novelty: 1.32691886
p_int: 0.994604217
p_ni: 0.004955784
p_wrong: 0.00044
Score: 0.379
Data Source: BioPlex,STRINGDB
LGALS1
Tchem
Novelty: 0.00106509
p_int: 0.750075331
p_ni: 0.249924636
p_wrong: 3.3e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.699
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.658
Data Source: STRINGDB
KLK14
Tchem
Family: Enzyme
Novelty: 0.02007434
Score: 0.648
Data Source: STRINGDB
CD300A
Tbio
Novelty: 0.01745189
Score: 0.636
Data Source: STRINGDB
LILRA1
Tdark
Novelty: 0.17371827
Score: 0.632
Data Source: STRINGDB
SIGLEC15
Tbio
Novelty: 0.04928596
Score: 0.626
Data Source: STRINGDB
LILRB1
Tbio
Novelty: 0.00463824
Score: 0.595
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.41

PubMed score by year
PubTator Score  63.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer