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Tbio
CFL2
Cofilin-2

Protein Summary
Description
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298159
  • ENSP00000298159
  • ENSG00000165410
  • ENST00000341223
  • ENSP00000340635
  • ENST00000555765
  • ENSP00000452451
  • ENST00000556161
  • ENSP00000452188

Symbol
  • NEM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.97
kinase perturbation
0.91
microRNA
0.9
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.62   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.62   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
67.9
1
1
0
1.1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
67.9
0
1.1
11.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cofilin 2
VGNC:7438
452853
Mouse
MGI:101763
12632
Rat
RGD:1306982
366624
Dog
cofilin 2
VGNC:39177
490649
Horse
cofilin 2
VGNC:16465
100050494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cofilin 2
Mouse
Rat
Dog
cofilin 2
Horse
cofilin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y281-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (89)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Axon guidance
KEGG
Fc gamma R-mediated phagocytosis
KEGG
Pertussis
KEGG
Regulation of actin cytoskeleton
KEGG
Human immunodeficiency virus 1 infection
Name
Explore in Pharos
Explore in Source
Axon guidance
Fc gamma R-mediated phagocytosis
Pertussis
Regulation of actin cytoskeleton
Human immunodeficiency virus 1 infection
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (116)
1 – 10 of 116
ACTG1
Tbio
Novelty: 0.00086444
Score: 0.991
Data Source: STRINGDB
ACTB
Tbio
Novelty: 0.00006048
Score: 0.99
Data Source: STRINGDB
LIMK1
Tchem
Family: Kinase
Novelty: 0.00349854
Score: 0.977
Data Source: STRINGDB
SSH1
Tbio
Family: Enzyme
Novelty: 0.02079383
Score: 0.939
Data Source: STRINGDB
LIMK2
Tchem
Family: Kinase
Novelty: 0.0153308
Score: 0.918
Data Source: STRINGDB
SSH2
Tbio
Family: Enzyme
Novelty: 0.05112042
Score: 0.885
Data Source: STRINGDB
SSH3
Tbio
Family: Enzyme
Novelty: 0.11388661
Score: 0.876
Data Source: STRINGDB
CFL1
Tbio
Novelty: 0.00071544
Score: 0.852
Data Source: STRINGDB
WDR1
Tbio
Novelty: 0.01524342
Score: 0.843
Data Source: STRINGDB
KBTBD13
Tbio
Novelty: 0.09921158
Score: 0.826
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.62

PubMed score by year
PubTator Score  26.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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