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Tbio
VSIG4
V-set and immunoglobulin domain-containing protein 4

Protein Summary
Description
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374737
  • ENSP00000363869
  • ENSG00000155659
  • ENST00000412866
  • ENSP00000394143
  • ENST00000455586
  • ENSP00000411581

Symbol
  • CRIg
  • Z39IG
  • CRIg
  • Z39IG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
protein domain
0.73
tissue sample
0.68
tissue
0.57
biological process
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.36   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.36   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (131)
1 – 10 of 131
INTS7
Tdark
Novelty: 0.11980396
p_int: 0.999291613
p_ni: 0.000708387
Data Source: BioPlex
SH3BP4
Tbio
Novelty: 0.1659751
p_int: 0.997949574
p_ni: 0.001661805
p_wrong: 0.000388621
Data Source: BioPlex
PKN3
Tbio
Family: Kinase
Novelty: 0.06193995
p_int: 0.993548722
p_ni: 0.006450762
p_wrong: 5.15e-7
Data Source: BioPlex
SLC25A23
Tbio
Family: Transporter
Novelty: 0.2047077
p_int: 0.989768833
p_ni: 0.010027393
p_wrong: 0.000203774
Data Source: BioPlex
TCAF2
Tbio
Family: Enzyme
Novelty: 1.15662651
p_int: 0.989710954
p_ni: 0.010286318
p_wrong: 0.000002728
Data Source: BioPlex
ZDHHC6
Tbio
Family: Enzyme
Novelty: 0.25862069
p_int: 0.987097695
p_ni: 0.00343083
p_wrong: 0.009471475
Data Source: BioPlex
MTFP1
Tbio
Novelty: 0.0389502
p_int: 0.986161184
p_ni: 0.012526962
p_wrong: 0.001311854
Data Source: BioPlex
POP4
Tbio
Family: Enzyme
Novelty: 0.02434459
p_int: 0.963574495
p_ni: 0.036425505
Data Source: BioPlex
PTCD2
Tdark
Novelty: 0.85714286
p_int: 0.962577644
p_ni: 0.037422356
Data Source: BioPlex
TIGD5
Tdark
Novelty: 2.52631579
p_int: 0.955708526
p_ni: 0.044291474
Data Source: BioPlex
Publication Statistics
PubMed Score  63.36

PubMed score by year
PubTator Score  28.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer