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Tbio
VDAC3
Voltage-dependent anion-selective channel protein 3

Protein Summary
Description
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000022615
  • ENSP00000022615
  • ENSG00000078668
  • ENST00000521158
  • ENSP00000428845

Symbol
  • VDAC-3
  • HD-VDAC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
co-expressed gene
0.94
molecular function
0.81
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.5   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.5   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (26)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Mitochondrial calcium ion transport
Reactome
Post-translational protein modification
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Mitochondrial calcium ion transport
Post-translational protein modification
Transport of small molecules
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (166)
1 – 10 of 166
APOE
Tbio
Novelty: 0.00005049
p_int: 0.999125127
p_ni: 0.000874846
p_wrong: 2.7e-8
Score: 0.225
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.995412425
p_ni: 0.004587565
p_wrong: 1e-8
Score: 0.2
Data Source: BioPlex,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.977028169
p_ni: 0.022970652
p_wrong: 0.000001179
Score: 0.459
Data Source: BioPlex,STRINGDB
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.969848434
p_ni: 0.030151566
Data Source: BioPlex
ERICH5
Tdark
Novelty: 5.57504212
p_int: 0.967773473
p_ni: 0.01224866
p_wrong: 0.019977867
Score: 0.175
Data Source: BioPlex,STRINGDB
FAM8A1
Tbio
Novelty: 0.08206001
p_int: 0.953831566
p_ni: 0.046168434
Data Source: BioPlex
SPATA19
Tbio
Novelty: 0.06203122
p_int: 0.81407268
p_ni: 0.18592732
Score: 0.209
Data Source: BioPlex,STRINGDB
RAP2A
Tbio
Family: Enzyme
Novelty: 0.00541101
p_int: 0.751432182
p_ni: 0.248567266
p_wrong: 5.52e-7
Score: 0.222
Data Source: BioPlex,STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
Score: 0.981
Data Source: STRINGDB
PPIF
Tchem
Family: Enzyme
Novelty: 0.00147732
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.50

PubMed score by year
PubTator Score  31.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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