You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TNFSF13B
Tumor necrosis factor ligand superfamily member 13B

Protein Summary
Description
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375887
  • ENSP00000365048
  • ENSG00000102524
  • ENST00000430559
  • ENSP00000389540
  • ENST00000542136
  • ENSP00000445334

Symbol
  • BAFF
  • BLYS
  • TALL1
  • TNFSF20
  • ZTNF4
  • DTL
  • BAFF
  • BLYS
  • CD257
  • TALL1
  • THANK
  • ZTNF4
  • TALL-1
  • TNLG7A
  • TNFSF20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
virus perturbation
0.98
disease
0.72
cell type or tissue
0.68
PubMedID
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1823.02   (req: < 5)
Gene RIFs: 366   (req: <= 3)
Antibodies: 1353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1823.02   (req: >= 5)
Gene RIFs: 366   (req: > 3)
Antibodies: 1353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
belimumab
no chemical structure image available
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
83.4
myeloid white cell count
2
2
2
82.4
tonsillectomy risk measurement
1
1
0
1.3
57.8
monocyte percentage of leukocytes
1
1
1
46.6
platelet crit
2
1
2
43.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
83.4
myeloid white cell count
2
82.4
tonsillectomy risk measurement
0
1.3
57.8
monocyte percentage of leukocytes
1
46.6
platelet crit
2
43.1
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (252)
1 – 10 of 252
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00144614
p_int: 1
Score: 0.268
Data Source: BioPlex,STRINGDB
MAP3K15
Tchem
Family: Kinase
Novelty: 0.12112018
p_int: 0.999999995
p_ni: 4e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
FAM160B1
Tdark
Novelty: 0.33441173
p_int: 0.999999965
p_ni: 2.7e-8
p_wrong: 8e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
HOOK2
Tbio
Novelty: 0.03559628
p_int: 0.999999905
p_ni: 9.2e-8
p_wrong: 3e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
MAP3K6
Tchem
Family: Kinase
Novelty: 0.03743265
p_int: 0.999999892
p_ni: 1.06e-7
p_wrong: 1e-9
Data Source: BioPlex
PDSS1
Tbio
Family: Enzyme
Novelty: 0.01542427
p_int: 0.999998495
p_ni: 0.00000133
p_wrong: 1.75e-7
Data Source: BioPlex
AKTIP
Tbio
Novelty: 0.00315951
p_int: 0.999995337
p_ni: 0.000003954
p_wrong: 7.08e-7
Score: 0.759
Data Source: BioPlex,STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.999881108
p_ni: 0.000118878
p_wrong: 1.4e-8
Data Source: BioPlex
FAM160A2
Tbio
Novelty: 1.08224895
p_int: 0.999634903
p_ni: 0.00002599
p_wrong: 0.000339107
Score: 0.817
Data Source: BioPlex,STRINGDB
HOOK1
Tbio
Novelty: 0.04136856
p_int: 0.999448658
p_ni: 0.000551341
Score: 0.307
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1823.02

PubMed score by year
PubTator Score  980.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: