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Tclin
CYSLTR1
Cysteinyl leukotriene receptor 1

Protein Summary
Description
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373304
  • ENSP00000362401
  • ENSG00000173198
  • ENST00000614798
  • ENSP00000478492

Symbol
  • CYSLT1
  • CYSLT1
  • CYSLTR
  • CYSLT1R
  • HMTMF81
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.7
ligand (chemical)
0.66
tissue sample
0.62
chemical
0.6
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 329.97   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 329.97   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 166
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (166)
LTE<sub>4</sub>
Rendered image for LTE<sub>4</sub>
LTC<sub>4</sub>
Rendered image for LTC<sub>4</sub>
LTD<sub>4</sub>
Rendered image for LTD<sub>4</sub>
N-methyl LTC<sub>4</sub>
Rendered image for N-methyl LTC<sub>4</sub>
BayCysLT<sub>2</sub>
Rendered image for BayCysLT<sub>2</sub>
BAYu9773
Rendered image for BAYu9773
iralukast
Rendered image for iralukast
MK-571
Rendered image for MK-571
pobilukast
Rendered image for pobilukast
Protein-Protein Interactions (197)
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.945
Data Source:  STRINGDB
CYSLTR2
Tchem
Family:  GPCR
Novelty:  0.00895224
Score:  0.944
Data Source:  STRINGDB
PTGER1
Tclin
Family:  GPCR
Novelty:  0.0013716
Score:  0.941
Data Source:  STRINGDB
GPR17
Tchem
Family:  GPCR
Novelty:  0.00545502
Score:  0.937
Data Source:  STRINGDB
LTB4R2
Tchem
Family:  GPCR
Novelty:  0.01094048
Score:  0.933
Data Source:  STRINGDB
LTB4R
Tchem
Family:  GPCR
Novelty:  0.00354427
Score:  0.924
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.923
Data Source:  STRINGDB
ANXA1
Tbio
Novelty:  0.00103537
Score:  0.919
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.918
Data Source:  STRINGDB
GPR143
Tbio
Family:  GPCR
Novelty:  0.01507388
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
potassium measurement
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
potassium measurement
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cysteinyl leukotriene receptor 1
706663
Mouse
MGI:1926218
58861
Rat
RGD:619796
114099
Dog
cysteinyl leukotriene receptor 1
VGNC:50295
100686426
Horse
cysteinyl leukotriene receptor 1
VGNC:50471
100072636
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cysteinyl leukotriene receptor 1
Mouse
Rat
Dog
cysteinyl leukotriene receptor 1
Horse
cysteinyl leukotriene receptor 1
Publication Statistics
PubMed Score 329.97
PubMed score by year
PubTator Score 269.56
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title