Tclin CYSLTR1 Cysteinyl leukotriene receptor 1

Protein Summary

Description

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9Y271
• B2R954
• D3DTE4
• Q5JS94
• Q8IV19
• CysLTR1

Gene Name

• CYSLTR1

Ensembl ID

• ENST00000373304
• ENSP00000362401
• ENSG00000173198
• ENST00000614798
• ENSP00000478492

Symbol

• CYSLT1
• CYSLT1
• CYSLTR
• CYSLT1R
• HMTMF81

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.7
ligand (chemical)	0.66
tissue sample	0.62
chemical	0.6
gene perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cysteinyl Leukotriene Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Leukotriene Receptor / Cysteinyl Leukotriene Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.43   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 295   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.43   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 166

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4