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Tdark
SLC22A14
Solute carrier family 22 member 14

Protein Summary
Description
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273173
  • ENSP00000273173
  • ENSG00000144671
  • ENST00000448498
  • ENSP00000396283

Symbol
  • OCTL2
  • ORCTL4
  • OCTL2
  • OCTL4
  • ORCTL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
gene perturbation
0.59
small molecule perturbation
0.59
tissue
0.57
cell line
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
XYLB
Tbio
Family:  Kinase
Novelty:  0.00540687
Score:  0.931
Data Source:  STRINGDB
OXSR1
Tbio
Family:  Kinase
Novelty:  0.11142923
Score:  0.8
Data Source:  STRINGDB
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
Score:  0.747
Data Source:  STRINGDB
SLCO5A1
Tbio
Family:  Transporter
Novelty:  0.17025746
Score:  0.738
Data Source:  STRINGDB
SLC6A9
Tchem
Family:  Transporter
Novelty:  0.05330871
Score:  0.709
Data Source:  STRINGDB
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
Score:  0.682
Data Source:  STRINGDB
ABCB5
Tbio
Family:  Transporter
Novelty:  0.00441025
Score:  0.66
Data Source:  STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.658
Data Source:  STRINGDB
ABCB6
Tbio
Family:  Transporter
Novelty:  0.00552057
Score:  0.635
Data Source:  STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
71.3
appendicular lean mass
1
1
1
46.1
bitter alcoholic beverage consumption measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
71.3
appendicular lean mass
1
46.1
bitter alcoholic beverage consumption measurement
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 14
VGNC:7999
747419
Macaque
solute carrier family 22 member 14
696120
Mouse
MGI:2685974
382113
Dog
solute carrier family 22 member 14
VGNC:46275
485588
Horse
solute carrier family 22 member 14
VGNC:23071
100053787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 14
Macaque
solute carrier family 22 member 14
Mouse
Dog
solute carrier family 22 member 14
Horse
solute carrier family 22 member 14
Publication Statistics
PubMed Score 4.09
PubMed score by year
PubTator Score 2.12
PubTator score by year
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Related Publications
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PMID
Year
Title