NUDC
Nuclear migration protein nudC
Protein Summary
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
- ENST00000321265
- ENSP00000319664
- ENSG00000090273
- HNUDC
- MNUDC
- NPD011
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 0.97 | ||
co-expressed gene | 0.94 | ||
protein complex | 0.94 | ||
histone modification site profile | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.41 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 356 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.41 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 356 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (258)
RRP9
Novelty: 0.07232317
p_int: 0.997992571
p_ni: 0.002007429
Score: 0.226
Data Source: BioPlex,STRINGDB
POC1B
Novelty: 0.09023863
p_int: 0.991649207
p_ni: 0.008350793
Score: 0.201
Data Source: BioPlex,STRINGDB
FBXW11
Novelty: 0.0715377
p_int: 0.990688593
p_ni: 0.009311407
Score: 0.524
Data Source: BioPlex,STRINGDB
BTRC
Novelty: 0.00293475
p_int: 0.987155771
p_ni: 0.012844229
Score: 0.54
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (20)
Reactome (17)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (52)
Items per page:
1 – 5 of 52
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 19 | 5 | 22 | 94.6 | |||||
triglyceride measurement | 19 | 4 | 20 | 94.5 | |||||
low density lipoprotein cholesterol measurement | 16 | 4 | 17 | 91.7 | |||||
C-reactive protein measurement | 4 | 1 | 5 | 91.3 | |||||
heel bone mineral density | 2 | 3 | 3 | 85.7 | |||||
Items per page:
1 – 5 of 52
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 22 | 94.6 | |||||
triglyceride measurement | 20 | 94.5 | |||||
low density lipoprotein cholesterol measurement | 17 | 91.7 | |||||
C-reactive protein measurement | 5 | 91.3 | |||||
heel bone mineral density | 3 | 85.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nuclear distribution C, dynein complex regulator | VGNC:1420 | 737457 | |||||
Macaque | nuclear distribution C, dynein complex regulator [Source:HGNC Symbol;Acc:HGNC:8045] | |||||||
Mouse | MGI:106014 | 18221 | ||||||
Rat | RGD:3215 | 29648 | ||||||
Dog | nuclear distribution C, dynein complex regulator | VGNC:44021 | 487349 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nuclear distribution C, dynein complex regulator | |||||
Macaque | nuclear distribution C, dynein complex regulator [Source:HGNC Symbol;Acc:HGNC:8045] | |||||
Mouse | ||||||
Rat | ||||||
Dog | nuclear distribution C, dynein complex regulator | |||||
Publication Statistics
PubMed Score 69.41
PubMed score by year
PubTator Score 36.07
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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