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Tbio
RUVBL1
RuvB-like 1

Protein Summary
Description
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also pl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322623
  • ENSP00000318297
  • ENSG00000175792
  • ENST00000643444
  • ENSP00000494621
  • ENSG00000284901

Symbol
  • INO80H
  • NMP238
  • TIP49
  • TIP49A
  • RVB1
  • TIH1
  • ECP54
  • TIP49
  • ECP-54
  • INO80H
  • NMP238
  • PONTIN
  • TIP49A
  • NMP 238
  • Pontin52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
1
protein complex
0.99
molecular function
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.56   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.56   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
73.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RuvB like AAA ATPase 1
VGNC:7119
460670
Macaque
RuvB like AAA ATPase 1
706044
Mouse
MGI:1928760
56505
Rat
RGD:68373
65137
Dog
RuvB like AAA ATPase 1
VGNC:45811
476512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RuvB like AAA ATPase 1
Macaque
RuvB like AAA ATPase 1
Mouse
Rat
Dog
RuvB like AAA ATPase 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y265-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Chromosome Maintenance
Reactome
DNA Damage Recognition in GG-NER
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromatin modifying enzymes
Chromatin organization
Chromosome Maintenance
DNA Damage Recognition in GG-NER
Gene Ontology Terms (41)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (559)
1 – 10 of 559
DPCD
Tbio
Novelty: 0.09869683
p_int: 0.99999999
p_ni: 9e-9
p_wrong: 1e-9
Score: 0.909
Data Source: BioPlex,STRINGDB
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
INO80
Tbio
Family: Enzyme
Novelty: 0.09412936
p_int: 0.999999986
p_ni: 1.3e-8
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
ACTR8
Tbio
Novelty: 0.12366847
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
ACTR5
Tbio
Novelty: 0.15502033
p_int: 0.999999863
p_ni: 1.37e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ING3
Tbio
Family: Epigenetic
Novelty: 0.01696145
p_int: 0.999999672
p_ni: 3.28e-7
Score: 0.97
Data Source: BioPlex,STRINGDB
EPC1
Tbio
Novelty: 0.03216371
p_int: 0.999999643
p_ni: 3.57e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
INO80B
Tbio
Novelty: 0.02405051
p_int: 0.999999533
p_ni: 2.34e-7
p_wrong: 2.33e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
NFRKB
Tbio
Novelty: 0.13445983
p_int: 0.999999382
p_ni: 6.18e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00368348
p_int: 0.999998939
p_ni: 0.000001061
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  115.56

PubMed score by year
PubTator Score  81.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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