Protein Classes
Protein Summary
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
- ENST00000381922
- ENSP00000371347
- ENSG00000101280
- ANG3
- ANG4
- ANG3
- ANG4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.88 | ||
protein domain | 0.73 | ||
gene perturbation | 0.62 | ||
cell type or tissue | 0.61 | ||
molecular function | 0.56 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.52 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 257 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.52 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 257 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
response to reverse transcriptase inhibitor | 1 | 1 | 0 | 28 | 1.2 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
response to reverse transcriptase inhibitor | 0 | 28 | 1.2 | ||||
Pathways (353)
Reactome (3)
KEGG (5)
PathwayCommons (1)
WikiPathways (344)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Reactome | Tie2 Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Tie2 Signaling | ||||
Gene Ontology Terms (15)
Functions (2)
Components (2)
Processes (11)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (36)
1 – 10 of 36
TEK
Family: Kinase
Novelty: 0.00079268
Score: 0.978
Data Source: Reactome,STRINGDB
ANGPT1
Novelty: 0.00115408
Score: 0.81
Data Source: STRINGDB
ANGPT2
Novelty: 0.00116183
Score: 0.81
Data Source: STRINGDB
TIE1
Family: Kinase
Novelty: 0.00550261
Score: 0.776
Data Source: STRINGDB
KDR
Family: Kinase
Novelty: 0.00016219
Score: 0.72
Data Source: STRINGDB
FLT4
Family: Kinase
Novelty: 0.001296
Score: 0.718
Data Source: STRINGDB
FLT1
Family: Kinase
Novelty: 0.00039648
Score: 0.716
Data Source: STRINGDB
PDGFRB
Family: Kinase
Novelty: 0.00074896
Score: 0.681
Data Source: STRINGDB
VPS51
Novelty: 0.01766125
Score: 0.652
Data Source: STRINGDB
MET
Family: Kinase
Novelty: 0.00037995
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score 32.52
PubMed score by year
PubTator Score 44.54
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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