Tbio ANGPT4 Angiopoietin-4

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Angiopoietin-4

DTO Classes

Protein / Signaling / Angiopoietin-4

Protein Summary

Description

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y264
• B4E3J9
• Q5TFF4
• Q9H4Z4
• ANG-4

Gene Name

• ANGPT4

Ensembl ID

• ENST00000381922
• ENSP00000371347
• ENSG00000101280

Symbol

• ANG3
• ANG4
• ANG3
• ANG4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
protein domain	0.73
gene perturbation	0.62
cell type or tissue	0.61
molecular function	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.3   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.3   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (353)

Reactome (3)

KEGG (5)

PathwayCommons (1)

WikiPathways (344)

Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Tie2 Signaling	18 targets	R-HSA-210993

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Hemostasis	666 targets	R-HSA-109582
Tie2 Signaling	18 targets	R-HSA-210993

Gene Ontology Terms (15)

Functions (2)

Components (2)

Processes (11)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
receptor tyrosine kinase binding	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane receptor protein tyrosine kinase activator activity	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

TEK

Tclin

Family: Kinase

Novelty: 0.00075841

Score: 0.978

Data Source: Reactome,STRINGDB

ANGPT1

Tbio

Novelty: 0.00129574

Score: 0.81

Data Source: STRINGDB

ANGPT2

Tbio

Novelty: 0.0014012

Score: 0.81

Data Source: STRINGDB

TIE1

Tchem

Family: Kinase

Novelty: 0.0033548

Score: 0.776

Data Source: STRINGDB

KDR

Tclin

Family: Kinase

Novelty: 0.00019671

Score: 0.72

Data Source: STRINGDB

FLT4

Tclin

Family: Kinase

Novelty: 0.00175479

Score: 0.718

Data Source: STRINGDB

FLT1

Tclin

Family: Kinase

Novelty: 0.00037168

Score: 0.716

Data Source: STRINGDB

PDGFRB

Tclin

Family: Kinase

Novelty: 0.00115144

Score: 0.681

Data Source: STRINGDB

VPS51

Tbio

Novelty: 0.04491738

Score: 0.652

Data Source: STRINGDB

MET

Tclin

Family: Kinase

Novelty: 0.00040613

Score: 0.631

Data Source: STRINGDB

Publication Statistics

PubMed Score  20.30

PubMed score by year

Reset Zoom

PubTator Score  44.54

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPEVSRDSNTLQR

1-70

ESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQQQMAQNQTAPMLELGTSLLN

70-140

QTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQLLLQRQKLQQLQGQNSALEKRLQALETKQQ

140-210

EELASILSKKAKLLNTLSRQSAALTNIERGLRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAF

210-280

IMAGEQVFQDCAEIQRSGASASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYK

280-350

QGFGDPAGEHWLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQ

350-420

SSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIRWHYFKGPSYS

420-490

LRASRMMIRPLDI

490-503

MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPEVSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQQQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQLLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERGLRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGASASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEHWLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQSSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIRWHYFKGPSYSLRASRMMIRPLDI

Find similar targets by:

Uniprot Keyword

Alternative splicing
Angiogenesis
Coiled coil
Complete proteome
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal