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Tbio
KCNK6
Potassium channel subfamily K member 6

Protein Summary
Description
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263372
  • ENSP00000263372
  • ENSG00000099337

Symbol
  • TOSS
  • TWIK2
  • TOSS
  • KCNK8
  • TWIK2
  • K2p6.1
  • TWIK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
virus perturbation
0.88
protein domain
0.73
PubMedID
0.6
histone modification site profile
0.54


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 6
VGNC:11171
468864
Mouse
MGI:1891291
52150
Rat
RGD:621450
116491
Dog
potassium two pore domain channel subfamily K member 6
VGNC:42278
484531
Horse
potassium two pore domain channel subfamily K member 6
VGNC:19300
100064140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 6
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 6
Horse
potassium two pore domain channel subfamily K member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y257-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (19)
1 – 10 of 19
NUDT6
Tbio
Novelty: 0.03648851
Score: 0.756
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.661
Data Source: STRINGDB
GLP2R
Tclin
Family: GPCR
Novelty: 0.02281665
Score: 0.635
Data Source: STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00404545
Score: 0.592
Data Source: STRINGDB
SLC24A3
Tbio
Family: Transporter
Novelty: 0.05923224
Score: 0.583
Data Source: STRINGDB
PPP1R27
Tdark
Family: Enzyme
Novelty: 0.72639115
Score: 0.518
Data Source: STRINGDB
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.517
Data Source: STRINGDB
DHX34
Tbio
Family: Enzyme
Novelty: 0.2185741
Score: 0.516
Data Source: STRINGDB
KCNH3
Tclin
Family: IC
Novelty: 0.05847445
Score: 0.51
Data Source: STRINGDB
KCNMB3
Tbio
Family: IC
Novelty: 0.08717845
Score: 0.47
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.75

PubMed score by year
PubTator Score  12.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer