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Tchem
RCE1
CAAX prenyl protease 2

Protein Summary
Description
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309657
  • ENSP00000309163
  • ENSG00000173653

Symbol
  • FACE2
  • RCE1A
  • RCE1B
  • FACE2
  • RCE1A
  • RCE1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.92
histone modification site profile
0.83
kinase perturbation
0.71
cellular component
0.69
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (77)
ICMT
Tchem
Family:  Enzyme
Novelty:  0.00706181
Score:  0.996
Data Source:  STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
Score:  0.976
Data Source:  STRINGDB
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
Score:  0.967
Data Source:  STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
Score:  0.965
Data Source:  STRINGDB
USP17L2
Tbio
Family:  Enzyme
Novelty:  0.06585454
Score:  0.961
Data Source:  Reactome,STRINGDB
CDC25A
Tchem
Family:  Enzyme
Novelty:  0.00250149
Score:  0.958
Data Source:  STRINGDB
USP17L5
Tdark
Family:  Enzyme
Novelty:  31.00671141
Score:  0.938
Data Source:  STRINGDB
USP17L3
Tdark
Family:  Enzyme
Novelty:  6.59346186
Score:  0.924
Data Source:  STRINGDB
USP17L8
Tdark
Family:  Enzyme
Novelty:  9.5249549
Score:  0.917
Data Source:  STRINGDB
USP17L4
Tdark
Family:  Enzyme
Novelty:  11.52
Score:  0.917
Data Source:  STRINGDB
Pathways (5)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
3
5
91.2
BMI-adjusted waist circumference
2
2
4
90.3
waist circumference
1
1
1
56.2
chronotype measurement
1
1
1
48.5
physical activity measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
91.2
BMI-adjusted waist circumference
4
90.3
waist circumference
1
56.2
chronotype measurement
1
48.5
physical activity measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras converting CAAX endopeptidase 1
VGNC:1027
451355
Macaque
Ras converting CAAX endopeptidase 1
713224
Mouse
MGI:1336895
19671
Rat
RGD:1309261
309153
Dog
Ras converting CAAX endopeptidase 1
483705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras converting CAAX endopeptidase 1
Macaque
Ras converting CAAX endopeptidase 1
Mouse
Rat
Dog
Ras converting CAAX endopeptidase 1
Publication Statistics
PubMed Score 77.85
PubMed score by year
PubTator Score 38.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title