You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRELID1
PRELI domain-containing protein 1, mitochondrial

Protein Summary
Description
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs. This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303204
  • ENSP00000302114
  • ENSG00000169230
  • ENST00000503216
  • ENSP00000427097

Symbol
  • PRELI
  • PX19
  • PRELI
  • SBBI12
  • CGI-106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.96
biological process
0.86
histone modification site profile
0.78
disease perturbation
0.68
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
27.2
heel bone mineral density
1
1
1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
27.2
heel bone mineral density
1
22.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PRELI domain containing 1
699254
Mouse
MGI:1913744
66494
Rat
RGD:1308082
290995
Dog
PRELI domain containing 1
VGNC:44955
479276
Horse
PRELI domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30255]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PRELI domain containing 1
Mouse
Rat
Dog
PRELI domain containing 1
Horse
PRELI domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30255]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y255-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (49)
1 – 10 of 49
TRIAP1
Tbio
Novelty: 0.00773097
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CRYAB
Tbio
Novelty: 0.00464213
p_int: 0.999966491
p_ni: 0.000033509
p_wrong: 1e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.999725352
p_ni: 0.000075475
p_wrong: 0.000199173
Data Source: BioPlex
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.849275471
p_ni: 0.000294507
p_wrong: 0.150430022
Score: 0.179
Data Source: BioPlex,STRINGDB
PRELID3A
Tbio
Novelty: 1.54594896
Score: 0.933
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.904
Data Source: STRINGDB
TAMM41
Tbio
Family: Enzyme
Novelty: 0.06004824
Score: 0.751
Data Source: STRINGDB
VPS37D
Tdark
Novelty: 1.44882563
Score: 0.748
Data Source: STRINGDB
ZFYVE28
Tbio
Novelty: 0.52872767
Score: 0.718
Data Source: STRINGDB
MXD3
Tbio
Family: TF
Novelty: 0.07436584
Score: 0.712
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.75

PubMed score by year
PubTator Score  5.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer