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Tchem
POLH
DNA polymerase eta

Protein Summary
Description
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372226
  • ENSP00000361300
  • ENSG00000170734
  • ENST00000372236
  • ENSP00000361310

Symbol
  • RAD30
  • RAD30A
  • XPV
  • XPV
  • XP-V
  • RAD30
  • RAD30A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.91
kinase perturbation
0.88
ligand (protein) perturbation
0.83
small molecule perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.55   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.55   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (122)
1 – 5 of 122
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (151)
1 – 10 of 151
LSM5
Tbio
Novelty: 0.09756098
p_int: 0.999999988
p_ni: 1.1e-8
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00268794
p_int: 0.999999909
p_ni: 8.8e-8
p_wrong: 3e-9
Data Source: BioPlex
POTEI
Tdark
Novelty: 0.30601093
p_int: 0.999945285
p_ni: 0.000054715
Score: 0.214
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.35273907
p_int: 0.968615606
p_ni: 0.031384394
Data Source: BioPlex
ACTB
Tbio
Novelty: 0.00027728
p_int: 0.916188575
p_ni: 0.083811425
Score: 0.19
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.02626744
p_int: 0.806268415
p_ni: 0.193731585
Data Source: BioPlex
AHNAK
Tbio
Novelty: 0.01530578
p_int: 0.798738745
p_ni: 0.201261255
Score: 0.189
Data Source: BioPlex,STRINGDB
PCNA
Tchem
Novelty: 0.00995674
Score: 0.999
Data Source: Reactome,STRINGDB
REV1
Tbio
Novelty: 0.00340661
Score: 0.99
Data Source: STRINGDB
RAD51
Tchem
Novelty: 0.00014377
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.55

PubMed score by year
PubTator Score  180.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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