Protein Summary
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose ...more
- ENST00000372226
- ENSP00000361300
- ENSG00000170734
- ENST00000372236
- ENSP00000361310
- RAD30
- RAD30A
- XPV
- XPV
- XP-V
- RAD30
- RAD30A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
histone modification site profile | 0.91 | ||
kinase perturbation | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
small molecule perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230.3 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230.3 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (151)
LSM5
Novelty: 0.12669584
p_int: 0.999999988
p_ni: 1.1e-8
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
POTEI
Novelty: 0.41311202
p_int: 0.999945285
p_ni: 0.000054715
Score: 0.214
Data Source: BioPlex,STRINGDB
ACTB
Novelty: 0.00006048
p_int: 0.916188575
p_ni: 0.083811425
Score: 0.19
Data Source: BioPlex,STRINGDB
AHNAK
Novelty: 0.01201996
p_int: 0.798738745
p_ni: 0.201261255
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (9)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | HDR through Homologous Recombination (HRR) | ||||
Reactome | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Damage Bypass | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
HDR through Homologous Recombination (HRR) | ||||
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (3)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 3 | 2 | 3 | 67.1 | |||||
platelet count | 2 | 1 | 2 | 42.1 | |||||
body height | 1 | 1 | 1 | 34.9 | |||||
refractive error | 1 | 1 | 1 | 13.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 3 | 67.1 | |||||
platelet count | 2 | 42.1 | |||||
body height | 1 | 34.9 | |||||
refractive error | 1 | 13.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA polymerase eta | VGNC:13033 | 462720 | |||||
Macaque | DNA polymerase eta | 700772 | ||||||
Mouse | MGI:1891457 | 80905 | ||||||
Rat | RGD:1309893 | 316235 | ||||||
Dog | DNA polymerase eta | VGNC:44783 | 474915 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA polymerase eta | |||||
Macaque | DNA polymerase eta | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA polymerase eta | |||||
Publication Statistics
PubMed Score 230.30
PubMed score by year
PubTator Score 180.78
PubTator score by year
Related Publications
Text Mined References (141)
GeneRif Annotations (121)
Items per page:
0 of 0
PMID | Year | Title |
|---|