Protein Summary
DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906). Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006). Although inserts the correct base, may cause base transitions and transversions depending upon the context. May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose ...more
- ENST00000372226
- ENSP00000361300
- ENSG00000170734
- ENST00000372236
- ENSP00000361310
- RAD30
- RAD30A
- XPV
- XPV
- XP-V
- RAD30
- RAD30A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
histone modification site profile | 0.91 | ||
kinase perturbation | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
small molecule perturbation | 0.79 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.55 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.55 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (2)
1 – 2 of 2
Protein Data Bank (122)
1 – 5 of 122
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (11)
Reactome (9)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | HDR through Homologous Recombination (HRR) | ||||
Reactome | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA Damage Bypass | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
HDR through Homologous Recombination (HRR) | ||||
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | ||||
Gene Ontology Terms (19)
Functions (3)
Components (5)
Processes (11)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (151)
1 – 10 of 151
LSM5
Novelty: 0.09756098
p_int: 0.999999988
p_ni: 1.1e-8
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
PIP
Novelty: 0.00268794
p_int: 0.999999909
p_ni: 8.8e-8
p_wrong: 3e-9
Data Source: BioPlex
POTEI
Novelty: 0.30601093
p_int: 0.999945285
p_ni: 0.000054715
Score: 0.214
Data Source: BioPlex,STRINGDB
ACTBL2
Novelty: 0.35273907
p_int: 0.968615606
p_ni: 0.031384394
Data Source: BioPlex
ACTB
Novelty: 0.00027728
p_int: 0.916188575
p_ni: 0.083811425
Score: 0.19
Data Source: BioPlex,STRINGDB
TUBA4A
Novelty: 0.02626744
p_int: 0.806268415
p_ni: 0.193731585
Data Source: BioPlex
AHNAK
Novelty: 0.01530578
p_int: 0.798738745
p_ni: 0.201261255
Score: 0.189
Data Source: BioPlex,STRINGDB
PCNA
Novelty: 0.00995674
Score: 0.999
Data Source: Reactome,STRINGDB
REV1
Novelty: 0.00340661
Score: 0.99
Data Source: STRINGDB
RAD51
Novelty: 0.00014377
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score 134.55
PubMed score by year
PubTator Score 180.78
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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