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Tchem
HPSE
Heparanase

Protein Summary
Description
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311412
  • ENSP00000308107
  • ENSG00000173083
  • ENST00000405413
  • ENSP00000384262
  • ENST00000509906
  • ENSP00000421038
  • ENST00000512196
  • ENSP00000423265
  • ENST00000513463
  • ENSP00000421365

Symbol
  • HEP
  • HPA
  • HPA1
  • HPR1
  • HPSE1
  • HSE1
  • HPA
  • HPA1
  • HPR1
  • HSE1
  • HPSE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor perturbation
0.74
interacting protein
0.73
biological process
0.72
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.64   (req: < 5)
Gene RIFs: 333   (req: <= 3)
Antibodies: 512   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 783.64   (req: >= 5)
Gene RIFs: 333   (req: > 3)
Antibodies: 512   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 125
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0