Tbio LZTS1 Leucine zipper putative tumor suppressor 1

Protein Summary

Description

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q9Y250
• D3DSQ6
• Q9Y5V7
• Q9Y5V8
• Q9Y5V9
• Q9Y5W0
• Q9Y5W1
• Q9Y5W2

Gene Name

• LZTS1

Ensembl ID

• ENST00000265801
• ENSP00000265801
• ENSG00000061337
• ENST00000381569
• ENSP00000370981
• ENST00000522290
• ENSP00000429263
• ENST00000616228
• ENSP00000479534

Symbol

• FEZ1
• F37
• FEZ1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
biological process	0.67
cellular component	0.67
microRNA	0.6
disease	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.52   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.52   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0