You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GINS2
DNA replication complex GINS protein PSF2

Protein Summary
Description
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253462
  • ENSP00000253462
  • ENSG00000131153

Symbol
  • PSF2
  • PSF2
  • Pfs2
  • HSPC037
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
histone modification site profile
0.82
virus perturbation
0.79
co-expressed gene
0.69
small molecule perturbation
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.56   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.56   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (232)
VPS54
Tbio
Novelty:  0.04428383
p_int:  0.999999994
p_ni:  5e-9
p_wrong:  1e-9
Data Source:  BioPlex
GINS1
Tbio
Novelty:  0.08722396
p_int:  0.999999922
p_ni:  7.8e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GINS4
Tbio
Novelty:  0.0316194
p_int:  0.999999909
p_ni:  8.9e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS50
Tbio
Novelty:  0.17236696
p_int:  0.999999901
p_ni:  9.9e-8
Data Source:  BioPlex
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.999999608
p_ni:  3.92e-7
Data Source:  BioPlex
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.999999581
p_ni:  4.19e-7
Data Source:  BioPlex
VPS53
Tbio
Novelty:  0.07513165
p_int:  0.999999145
p_ni:  8.55e-7
Data Source:  BioPlex
GINS3
Tbio
Novelty:  0.02892519
p_int:  0.999998859
p_ni:  0.00000114
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS51
Tbio
Novelty:  0.01766125
p_int:  0.999977861
p_ni:  0.000022137
p_wrong:  1e-9
Data Source:  BioPlex
SIK1
Tchem
Family:  Kinase
Novelty:  0.00523549
p_int:  0.999969488
p_ni:  0.000030502
p_wrong:  1e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
DNA Replication
Reactome
DNA strand elongation
Reactome
S Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
DNA Replication
DNA strand elongation
S Phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
3
3
87.6
platelet count
2
2
2
80.3
eosinophil count
2
2
3
74
alcohol consumption measurement
2
2
2
60.1
mean platelet volume
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
3
87.6
platelet count
2
80.3
eosinophil count
3
74
alcohol consumption measurement
2
60.1
mean platelet volume
1
59.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GINS complex subunit 2
VGNC:9079
454293
Macaque
GINS complex subunit 2
693426
Mouse
MGI:1921019
272551
Rat
RGD:1311055
292058
Dog
GINS complex subunit 2
VGNC:41221
609436
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GINS complex subunit 2
Macaque
GINS complex subunit 2
Mouse
Rat
Dog
GINS complex subunit 2
Publication Statistics
PubMed Score 153.56
PubMed score by year
PubTator Score 68.09
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title