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Tchem
AKT3
RAC-gamma serine/threonine-protein kinase

Protein Classes
Protein Summary
Description
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. The protein encoded by this gene i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263826
  • ENSP00000263826
  • ENSG00000117020
  • ENST00000336199
  • ENSP00000336943
  • ENST00000366539
  • ENSP00000355497
  • ENST00000366540
  • ENSP00000355498
  • ENST00000613395
  • ENSP00000479922
  • ENSG00000275199
  • ENST00000619536
  • ENSP00000483054
  • ENST00000621586
  • ENSP00000479081

Symbol
  • PKBG
  • MPPH
  • PKBG
  • MPPH2
  • PRKBG
  • STK-2
  • PKB-GAMMA
  • RAC-gamma
  • RAC-PK-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.94
molecular function
0.91
microRNA
0.89
pathway
0.88


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.22   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 1054   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.22   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 1054   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 84
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
94.4
body mass index
2
2
2
94.4
body height
2
2
2
91.2
body height
2
2
2
91.2
5
3
0
1.1
86.1
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
94.4
body mass index
2
94.4
body height
2
91.2
body height
2
91.2
0
1.1
86.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AKT serine/threonine kinase 3
VGNC:11733
100609583
Macaque
AKT serine/threonine kinase 3
714717
Mouse
MGI:1345147
23797
Rat
RGD:62390
29414
Dog
AKT serine/threonine kinase 3
VGNC:37773
442964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AKT serine/threonine kinase 3
Macaque
AKT serine/threonine kinase 3
Mouse
Rat
Dog
AKT serine/threonine kinase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y243-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (228)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 67
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
AKT phosphorylates targets in the nucleus
Reactome
AKT-mediated inactivation of FOXO1A
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Protein-Protein Interactions (255)
1 – 10 of 255
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
p_int: 1
Score: 0.931
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.999999931
p_ni: 6.9e-8
Data Source: BioPlex
HSP90AB3P
Tdark
p_int: 0.999999803
p_ni: 1.63e-7
p_wrong: 3.4e-8
Data Source: BioPlex
HSP90AA4P
Tdark
p_int: 0.999999593
p_ni: 4.07e-7
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999980123
p_ni: 0.000019839
p_wrong: 3.8e-8
Data Source: BioPlex
PIANP
Tbio
Novelty: 0.01739512
p_int: 0.999037769
p_ni: 0.000947426
p_wrong: 0.000014805
Score: 0.214
Data Source: BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
p_int: 0.995089712
p_ni: 0.004910288
Score: 0.911
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.99239221
p_ni: 0.00760779
Score: 0.346
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
p_int: 0.992265865
p_ni: 0.007734135
Score: 0.987
Data Source: BioPlex,STRINGDB
CDC37
Tbio
Novelty: 0.03730196
p_int: 0.986072309
p_ni: 0.013927691
Score: 0.758
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  282.22

PubMed score by year
PubTator Score  159.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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