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Tchem
NOD1
Nucleotide-binding oligomerization domain-containing protein 1

Protein Summary
Description
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and pa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222823
  • ENSP00000222823
  • ENSG00000106100

Symbol
  • CARD4
  • CARD4
  • NLRC1
  • CLR7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.98
biological term
0.92
virus perturbation
0.85
histone modification site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.99   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 462.99   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
40
reticulocyte count
2
1
2
35.7
reticulocyte measurement
2
1
2
32.9
mean reticulocyte volume
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
40
reticulocyte count
2
35.7
reticulocyte measurement
2
32.9
mean reticulocyte volume
1
13.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding oligomerization domain containing 1
VGNC:14056
472336
Macaque
nucleotide binding oligomerization domain containing 1
695655
Mouse
MGI:1341839
107607
Rat
RGD:1562269
500133
Dog
nucleotide binding oligomerization domain containing 1
VGNC:43877
482382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding oligomerization domain containing 1
Macaque
nucleotide binding oligomerization domain containing 1
Mouse
Rat
Dog
nucleotide binding oligomerization domain containing 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y239-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
Immune System
Innate Immune System
Interleukin-1 family signaling
Gene Ontology Terms (41)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
RIPK2
Tchem
Family: Kinase
Novelty: 0.00574043
Score: 0.997
Data Source: Reactome,STRINGDB
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.984
Data Source: STRINGDB
CARD9
Tbio
Family: Enzyme
Novelty: 0.00547101
Score: 0.972
Data Source: Reactome,STRINGDB
ATG16L1
Tbio
Novelty: 0.0031765
Score: 0.958
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.956
Data Source: STRINGDB
CASP4
Tchem
Family: Enzyme
Novelty: 0.00461865
Score: 0.955
Data Source: STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.954
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.951
Data Source: Reactome,STRINGDB
CASP9
Tchem
Family: Enzyme
Novelty: 0.00023687
Score: 0.949
Data Source: STRINGDB
NOD2
Tclin
Novelty: 0.00059089
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  462.99

PubMed score by year
PubTator Score  229.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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