Tbio PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Protein Summary

Description

Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• Q9Y237
• A8E0G6
• B3KXM0
• F5H1P5
• Q0D2H3
• Q3MHV0
• Q52M21
• Q5HYW6
• Q6IRW4

Gene Name

• PIN4

Ensembl ID

• ENST00000373669
• ENSP00000362773
• ENSG00000102309
• ENST00000423432
• ENSP00000409154

Symbol

• EPVH
• PAR14
• PAR17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
hub protein	0.88
disease perturbation	0.87
transcription factor perturbation	0.8
cellular component	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.49   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.49   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0