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Tbio
PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Protein Summary
Description
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA. This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373669
  • ENSP00000362773
  • ENSG00000102309
  • ENST00000423432
  • ENSP00000409154

Symbol
  • EPVH
  • PAR14
  • PAR17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
hub protein
0.88
disease perturbation
0.87
transcription factor perturbation
0.8
cellular component
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.38   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.38   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
CHST15
Tbio
Family:  Enzyme
Novelty:  0.03950241
p_int:  0.992080053
p_ni:  0.005759296
p_wrong:  0.002160651
Score:  0.68
Data Source:  BioPlex,STRINGDB
SCO2
Tbio
Novelty:  0.00680753
Score:  0.833
Data Source:  STRINGDB
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.822
Data Source:  STRINGDB
RRBP1
Tbio
Novelty:  0.01494613
Score:  0.82
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.775
Data Source:  STRINGDB
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
Score:  0.768
Data Source:  STRINGDB
RNF44
Tdark
Novelty:  2.71629373
Score:  0.764
Data Source:  STRINGDB
PFDN5
Tbio
Novelty:  0.07673574
Score:  0.739
Data Source:  STRINGDB
NKTR
Tbio
Novelty:  0.01287691
Score:  0.711
Data Source:  STRINGDB
SNX12
Tbio
Novelty:  0.16113428
Score:  0.7
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
54.3
sodium measurement
1
1
1
42.2
platelet crit
1
1
1
35
chloride measurement
1
1
1
33
platelet count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
54.3
sodium measurement
1
42.2
platelet crit
1
35
chloride measurement
1
33
platelet count
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
699273
Mouse
MGI:1916963
69713
Rat
RGD:1590326
684441
Dog
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
100687619
Cow
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
VGNC:32903
100126055
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Mouse
Rat
Dog
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Cow
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Publication Statistics
PubMed Score 82.38
PubMed score by year
PubTator Score 49.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title