You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
APOBEC2
C->U-editing enzyme APOBEC-2

Protein Summary
Description
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244669
  • ENSP00000244669
  • ENSG00000124701

Symbol
  • ARP1
  • ARCD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.73
molecular function
0.6
tissue sample
0.59
small molecule perturbation
0.54
biological process
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.83   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.83   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
APOBEC4
Tdark
Novelty:  0.13240154
Score:  0.99
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.954
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.943
Data Source:  STRINGDB
APOBEC3H
Tbio
Novelty:  0.01600106
Score:  0.924
Data Source:  STRINGDB
APOBEC3B
Tbio
Novelty:  0.008531
Score:  0.92
Data Source:  STRINGDB
APOBEC3A
Tchem
Novelty:  0.00982993
Score:  0.919
Data Source:  STRINGDB
APOBEC3C
Tbio
Novelty:  0.00882074
Score:  0.913
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.803
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.799
Data Source:  STRINGDB
UNC45B
Tbio
Novelty:  0.01872121
Score:  0.768
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
late-onset Alzheimers disease
2
3
0
1.7
90.5
2
3
0
5.5
79.3
C-C motif chemokine 20 measurement
1
1
1
68.8
family history of Alzheimer’s disease
1
2
0
6.9
67.4
mean corpuscular volume
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
late-onset Alzheimers disease
0
1.7
90.5
0
5.5
79.3
C-C motif chemokine 20 measurement
1
68.8
family history of Alzheimer’s disease
0
6.9
67.4
mean corpuscular volume
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 2
VGNC:11031
462675
Macaque
apolipoprotein B mRNA editing enzyme catalytic subunit 2
719677
Mouse
MGI:1343178
11811
Rat
RGD:1308727
301226
Dog
apolipoprotein B mRNA editing enzyme catalytic subunit 2
VGNC:37996
481788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein B mRNA editing enzyme catalytic subunit 2
Macaque
apolipoprotein B mRNA editing enzyme catalytic subunit 2
Mouse
Rat
Dog
apolipoprotein B mRNA editing enzyme catalytic subunit 2
Publication Statistics
PubMed Score 25.83
PubMed score by year
PubTator Score 15.11
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title