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Tbio
APOBEC2
C->U-editing enzyme APOBEC-2

Protein Summary
Description
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244669
  • ENSP00000244669
  • ENSG00000124701

Symbol
  • ARP1
  • ARCD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.73
molecular function
0.6
tissue sample
0.59
small molecule perturbation
0.54
biological process
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.29   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.29   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (40)
1 – 10 of 40
APOBEC4
Tdark
Novelty: 0.13240154
Score: 0.99
Data Source: STRINGDB
APOBEC1
Tbio
Novelty: 0.00622042
Score: 0.954
Data Source: STRINGDB
A1CF
Tbio
Novelty: 0.04151936
Score: 0.943
Data Source: STRINGDB
APOBEC3H
Tbio
Novelty: 0.01600106
Score: 0.924
Data Source: STRINGDB
APOBEC3B
Tbio
Novelty: 0.008531
Score: 0.92
Data Source: STRINGDB
APOBEC3A
Tbio
Novelty: 0.00982993
Score: 0.919
Data Source: STRINGDB
APOBEC3C
Tbio
Novelty: 0.00882074
Score: 0.913
Data Source: STRINGDB
CDA
Tchem
Family: Enzyme
Novelty: 0.00280981
Score: 0.803
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.799
Data Source: STRINGDB
UNC45B
Tbio
Novelty: 0.01872121
Score: 0.768
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.29

PubMed score by year
PubTator Score  15.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer