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Tdark
LIPT1
Lipoyltransferase 1, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes. The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393471
  • ENSP00000377114
  • ENSG00000144182
  • ENST00000393473
  • ENSP00000377115

Symbol
  • LIPT1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
tissue sample
0.75
virus perturbation
0.72
transcription factor binding site profile
0.71
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
3
81.6
reticulocyte count
2
2
3
80
intelligence
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
81.6
reticulocyte count
3
80
intelligence
1
24.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lipoyltransferase 1
708812
Mouse
MGI:3645211
623661
Rat
RGD:1310276
316342
Dog
lipoyltransferase 1
VGNC:42701
111089955
Horse
lipoyltransferase 1
VGNC:19690
100050813
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lipoyltransferase 1
Mouse
Rat
Dog
lipoyltransferase 1
Horse
lipoyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y234-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (59)
1 – 10 of 59
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.999579721
p_ni:  0.000420056
p_wrong:  2.23e-7
Score:  0.965
Data Source:  BioPlex,STRINGDB
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.998346019
p_ni:  0.00165391
p_wrong:  7.1e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
METTL15
Tdark
Family:  Enzyme
Novelty:  0.4575663
p_int:  0.995453435
p_ni:  0.004546557
p_wrong:  8e-9
Score:  0.373
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.987398176
p_ni:  0.012601824
Score:  0.177
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.929420074
p_ni:  0.070578297
p_wrong:  0.000001628
Score:  0.163
Data Source:  BioPlex,STRINGDB
LIPT2
Tbio
Family:  Enzyme
Novelty:  0.31022396
Score:  0.992
Data Source:  STRINGDB
GCSH
Tbio
Novelty:  0.02101972
Score:  0.992
Data Source:  STRINGDB
LIAS
Tbio
Family:  Enzyme
Novelty:  0.01269062
Score:  0.99
Data Source:  STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.976
Data Source:  STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.976
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.84

PubMed score by year
PubTator Score  4.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer