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Tclin
PDE10A
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Protein Summary
Description
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366882
  • ENSP00000355847
  • ENSG00000112541
  • ENST00000650117
  • ENSP00000497426

Symbol
  • ADSD2
  • IOLOD
  • HSPDE10A
  • PDE10A19
  • LINC00473
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.94
protein domain
0.85
microRNA
0.77
PubMedID
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.55   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.55   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3959
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid stimulating hormone measurement
2
2
3
91.9
birth weight
2
2
2
89.8
lifestyle measurement
1
1
1
86.9
hormone measurement
1
1
3
84
2
2
1
1.1
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid stimulating hormone measurement
3
91.9
birth weight
2
89.8
lifestyle measurement
1
86.9
hormone measurement
3
84
1
1.1
70.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 10A
VGNC:7902
463123
Macaque
phosphodiesterase 10A
714983
Mouse
MGI:1345143
23984
Rat
RGD:68434
63885
Dog
phosphodiesterase 10A
VGNC:44345
484073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 10A
Macaque
phosphodiesterase 10A
Mouse
Rat
Dog
phosphodiesterase 10A
Protein Structure (86 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 86
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Hemostasis
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (102)
1 – 10 of 102
CSN1S1
Tbio
Family: Enzyme
Novelty: 0.00200522
p_int: 0.999108752
p_ni: 8.3e-8
p_wrong: 0.000891166
Score: 0.379
Data Source: BioPlex,STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.906
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.905
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.904
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.904
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.903
Data Source: STRINGDB
ADCY8
Tbio
Family: Enzyme
Novelty: 0.00510386
Score: 0.821
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.821
Data Source: STRINGDB
ADCY1
Tchem
Family: Enzyme
Novelty: 0.01089602
Score: 0.808
Data Source: STRINGDB
ADCY10
Tchem
Family: Enzyme
Novelty: 0.00037654
Score: 0.801
Data Source: STRINGDB
Publication Statistics
PubMed Score  328.55

PubMed score by year
PubTator Score  141.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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