Protein Summary
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also pl ...more
- ENST00000595090
- ENSP00000473172
- ENSG00000183207
- INO80J
- TIP48
- TIP49B
- RVB2
- TIH2
- ECP51
- TIP48
- CGI-46
- ECP-51
- INO80J
- REPTIN
- TIP49B
- TAP54-beta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
molecular function | 1 | ||
protein complex | 0.99 | ||
biological process | 0.97 | ||
co-expressed gene | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.38 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 367 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.38 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 367 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (407)
DPCD
Novelty: 0.09869683
p_int: 0.999999996
p_ni: 2e-9
p_wrong: 2e-9
Score: 0.854
Data Source: BioPlex,STRINGDB
RUVBL1
Novelty: 0.0089115
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR8
Novelty: 0.12366847
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
INO80D
Novelty: 0.33070971
p_int: 0.999999922
p_ni: 3.7e-8
p_wrong: 4.1e-8
Score: 0.792
Data Source: BioPlex,STRINGDB
ACTR5
Novelty: 0.15502033
p_int: 0.999999899
p_ni: 1e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
INO80B
Novelty: 0.02405051
p_int: 0.999999509
p_ni: 4.59e-7
p_wrong: 3.2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
NFRKB
Novelty: 0.13445983
p_int: 0.99999939
p_ni: 6.1e-7
Score: 0.929
Data Source: BioPlex,STRINGDB
WDCP
Novelty: 0.29184907
p_int: 0.999996505
p_ni: 0.000003495
Score: 0.313
Data Source: BioPlex,STRINGDB
EPC2
Novelty: 0.02760809
p_int: 0.999995435
p_ni: 0.000004565
Score: 0.906
Data Source: BioPlex,STRINGDB
EPC1
Novelty: 0.03216371
p_int: 0.999994611
p_ni: 0.000005389
Score: 0.976
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (8)
PathwayCommons (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | Extension of Telomeres | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Chromosome Maintenance | ||||
Extension of Telomeres | ||||
Viral Interactions (0)
Gene Ontology Terms (50)
Functions (16)
Components (15)
Processes (19)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 6 | 6 | 6 | 88 | |||||
eosinophil count | 3 | 1 | 3 | 70.9 | |||||
systolic blood pressure | 1 | 1 | 1 | 67.7 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 53.7 | |||||
lymphocyte count | 1 | 1 | 1 | 51.7 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 6 | 88 | |||||
eosinophil count | 3 | 70.9 | |||||
systolic blood pressure | 1 | 67.7 | |||||
eosinophil percentage of leukocytes | 1 | 53.7 | |||||
lymphocyte count | 1 | 51.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | RuvB like AAA ATPase 2 | VGNC:8324 | 468949 | |||||
Macaque | RuvB like AAA ATPase 2 | 100428794 | ||||||
Mouse | MGI:1342299 | 20174 | ||||||
Rat | RGD:1306509 | 292907 | ||||||
Dog | RuvB like AAA ATPase 2 | VGNC:45812 | 476418 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | RuvB like AAA ATPase 2 | |||||
Macaque | RuvB like AAA ATPase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | RuvB like AAA ATPase 2 | |||||
Publication Statistics
PubMed Score 101.38
PubMed score by year
PubTator Score 85.80
PubTator score by year
Related Publications
Text Mined References (96)
GeneRif Annotations (48)
Items per page:
0 of 0
PMID | Year | Title |
---|