Tbio RUVBL2 RuvB-like 2

Protein Summary

Description

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y230
• B3KQ59
• E7ETE5
• Q6FIB9
• Q6PK27
• Q9Y361

Gene Name

• RUVBL2

Ensembl ID

• ENST00000595090
• ENSP00000473172
• ENSG00000183207

Symbol

• INO80J
• TIP48
• TIP49B
• RVB2
• TIH2
• ECP51
• TIP48
• CGI-46
• ECP-51
• INO80J
• REPTIN
• TIP49B
• TAP54-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
protein complex	0.99
biological process	0.97
co-expressed gene	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.38   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 367   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.38   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (407)

Explore Interacting Targets

1 – 10 of 407

• See Interactions on String-DB

DPCD

Tbio

Novelty:  0.09869683

p_int:  0.999999996

p_ni:  2e-9

p_wrong:  2e-9

Score:  0.854

Data Source:  BioPlex,STRINGDB

RUVBL1

Tbio

Novelty:  0.0089115

p_int:  0.999999989

p_ni:  1.1e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR8

Tbio

Novelty:  0.12366847

p_int:  0.999999962

p_ni:  3.8e-8

Score:  0.986

Data Source:  BioPlex,STRINGDB

INO80D

Tdark

Novelty:  0.33070971

p_int:  0.999999922

p_ni:  3.7e-8

p_wrong:  4.1e-8

Score:  0.792

Data Source:  BioPlex,STRINGDB

ACTR5

Tbio

Novelty:  0.15502033

p_int:  0.999999899

p_ni:  1e-7

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

INO80B

Tbio

Novelty:  0.02405051

p_int:  0.999999509

p_ni:  4.59e-7

p_wrong:  3.2e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

NFRKB

Tbio

Novelty:  0.13445983

p_int:  0.99999939

p_ni:  6.1e-7

Score:  0.929

Data Source:  BioPlex,STRINGDB

WDCP

Tdark

Novelty:  0.29184907

p_int:  0.999996505

p_ni:  0.000003495

Score:  0.313

Data Source:  BioPlex,STRINGDB

EPC2

Tbio

Novelty:  0.02760809

p_int:  0.999995435

p_ni:  0.000004565

Score:  0.906

Data Source:  BioPlex,STRINGDB

EPC1

Tbio

Novelty:  0.03216371

p_int:  0.999994611

p_ni:  0.000005389

Score:  0.976

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (8)

PathwayCommons (5)

Cell Cycle (R-HSA-1640170)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Chromosome Maintenance	88 targets	R-HSA-73886
Reactome	Extension of Telomeres	30 targets	R-HSA-180786

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Chromosome Maintenance	88 targets	R-HSA-73886
Extension of Telomeres	30 targets	R-HSA-180786

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (50)

Functions (16)

Components (15)

Processes (19)

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1 – 10 of 16

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Direct Assay (IDA)	UniProtKB
chromatin DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA helicase activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II core promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
TBP-class protein binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription corepressor activity	Inferred from Direct Assay (IDA)	UniProtKB
ATP-dependent DNA helicase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
unfolded protein binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (13)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	6	6	6		88
eosinophil count	EFO_0004842	3	1	3		70.9
systolic blood pressure	EFO_0006335	1	1	1		67.7
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		53.7
lymphocyte count	EFO_0004587	1	1	1		51.7

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	6		88
eosinophil count	EFO_0004842	3		70.9
systolic blood pressure	EFO_0006335	1		67.7
eosinophil percentage of leukocytes	EFO_0007991	1		53.7
lymphocyte count	EFO_0004587	1		51.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Alternative splicing
ATP-binding
Chromatin regulator
Complete proteome
Cytoplasm
Direct protein sequencing
DNA damage

GWAS Trait Find Similar Targets

No Header	No Header
electrocardiography
eosinophil count
eosinophil percentage of leukocytes
ferritin measurement
heel bone mineral density
leukocyte count
lymphocyte count
neutrophil percentage of granulocytes
platelet crit
puberty onset measurement

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
mortality/aging
pigmentation phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RuvB like AAA ATPase 2	VGNC:8324	468949
Macaque	RuvB like AAA ATPase 2		100428794
Mouse	RuvB-like protein 2	MGI:1342299	20174
Rat	RuvB-like AAA ATPase 2	RGD:1306509	292907
Dog	RuvB like AAA ATPase 2	VGNC:45812	476418

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RuvB like AAA ATPase 2
Macaque	RuvB like AAA ATPase 2
Mouse	RuvB-like protein 2
Rat	RuvB-like AAA ATPase 2
Dog	RuvB like AAA ATPase 2

Publication Statistics

PubMed Score 101.38

PubMed score by year

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PubTator Score 85.80

PubTator score by year

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Related Publications

Text Mined References (96)

GeneRif Annotations (48)

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PMID	Year	Title