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Tbio
TRAF3IP3
TRAF3-interacting JNK-activating modulator

Protein Classes
Protein Summary
Description
May function as an adapter molecule that regulates TRAF3-mediated JNK activation. The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367024
  • ENSP00000355991
  • ENSG00000009790
  • ENST00000367025
  • ENSP00000355992
  • ENST00000367026
  • ENSP00000355993
  • ENST00000478359
  • ENSP00000417665

Symbol
  • T3JAM
  • T3JAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
kinase perturbation
0.88
cell type or tissue
0.73
tissue sample
0.68
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
74.2
Oral cleft
1
1
1
43
mean corpuscular volume
1
1
1
36
erythrocyte count
1
1
1
19.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
74.2
Oral cleft
1
43
mean corpuscular volume
1
36
erythrocyte count
1
19.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRAF3 interacting protein 3
VGNC:1698
457699
Macaque
TRAF3 interacting protein 3
712895
Mouse
MGI:2441706
215243
Rat
RGD:1304848
360900
Dog
TRAF3 interacting protein 3
VGNC:47767
480014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRAF3 interacting protein 3
Macaque
TRAF3 interacting protein 3
Mouse
Rat
Dog
TRAF3 interacting protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y228-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (104)
1 – 10 of 104
FGFR1OP2
Tbio
Novelty: 0.1082136
p_int: 1
Score: 0.86
Data Source: BioPlex,STRINGDB
SIKE1
Tbio
Novelty: 0.14549184
p_int: 0.999999991
p_ni: 9e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
STRIP2
Tbio
Novelty: 0.19321125
p_int: 0.999999988
p_ni: 3e-9
p_wrong: 8e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
STRIP1
Tbio
Novelty: 0.13320106
p_int: 0.999999848
p_ni: 1.52e-7
p_wrong: 1e-9
Score: 0.86
Data Source: BioPlex,STRINGDB
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.999998805
p_ni: 0.000001195
Score: 0.87
Data Source: BioPlex,STRINGDB
STRN
Tbio
Novelty: 0.01025814
p_int: 0.999998045
p_ni: 0.000001955
Score: 0.865
Data Source: BioPlex,STRINGDB
STRN4
Tbio
Novelty: 0.09936184
p_int: 0.999997023
p_ni: 0.000002977
Score: 0.862
Data Source: BioPlex,STRINGDB
RGPD8
Tdark
Novelty: 0.12397737
p_int: 0.999994765
p_ni: 0.000005235
Data Source: BioPlex
MOB4
Tbio
Novelty: 0.03238981
p_int: 0.99996412
p_ni: 0.000005714
p_wrong: 0.000030166
Score: 0.892
Data Source: BioPlex,STRINGDB
RGPD5
Tbio
Novelty: 0.13776125
p_int: 0.99947679
p_ni: 0.00052321
Data Source: BioPlex
Publication Statistics
PubMed Score  10.45

PubMed score by year
PubTator Score  3.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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