Tbio RTRAF RNA transcription, translation and transport factor protein

Protein Summary

Description

RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).

Uniprot Accession IDs

• Q9Y224

Gene Name

• RTRAF

Ensembl ID

• ENST00000261700
• ENSP00000261700
• ENSG00000087302

Symbol

• C14orf166
• CLE
• CLE7
• hCLE
• CGI99
• RLLM1
• hCLE1
• CGI-99
• LCRP369
• C14orf166

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.49   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.49   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0