You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RTRAF
RNA transcription, translation and transport factor protein

Protein Summary
Description
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261700
  • ENSP00000261700
  • ENSG00000087302

Symbol
  • C14orf166
  • CLE
  • CLE7
  • hCLE
  • CGI99
  • RLLM1
  • hCLE1
  • CGI-99
  • LCRP369
  • C14orf166
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.08   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.08   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
RTCB
Tbio
Family:  Enzyme
Novelty:  0.01114311
Score:  0.999
Data Source:  STRINGDB
FAM98B
Tdark
Novelty:  0.47641513
Score:  0.999
Data Source:  STRINGDB
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
Score:  0.999
Data Source:  STRINGDB
C2orf49
Tbio
Novelty:  0.03911934
Score:  0.997
Data Source:  STRINGDB
FAM98A
Tdark
Novelty:  0.30067413
Score:  0.996
Data Source:  STRINGDB
ZBTB8OS
Tbio
Family:  Enzyme
Novelty:  0.03929334
Score:  0.947
Data Source:  STRINGDB
NIN
Tbio
Novelty:  0.01312714
Score:  0.901
Data Source:  STRINGDB
PSMG1
Tbio
Novelty:  0.08175356
Score:  0.887
Data Source:  STRINGDB
PSMA3
Tbio
Family:  Enzyme
Novelty:  0.03106507
Score:  0.882
Data Source:  STRINGDB
FAM98C
Tdark
Novelty:  14.23728814
Score:  0.864
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
3
4
81.3
waist-hip ratio
1
3
3
52.3
age-related hearing impairment
1
1
0
6.5
46.1
body mass index
1
1
1
44.2
triglyceride measurement
2
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
81.3
waist-hip ratio
3
52.3
age-related hearing impairment
0
6.5
46.1
body mass index
1
44.2
triglyceride measurement
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA transcription, translation and transport factor
VGNC:3469
452904
Macaque
RNA transcription, translation and transport factor
710094
Mouse
MGI:1915295
68045
Rat
RGD:1304704
302247
Dog
RNA transcription, translation and transport factor
610819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA transcription, translation and transport factor
Macaque
RNA transcription, translation and transport factor
Mouse
Rat
Dog
RNA transcription, translation and transport factor
Publication Statistics
PubMed Score 31.08
PubMed score by year
PubTator Score 40.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title