GNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Protein Summary
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alte ...more
- ENST00000377902
- ENSP00000367134
- ENSG00000159921
- ENST00000396594
- ENSP00000379839
- ENST00000447283
- ENSP00000414760
- ENST00000539208
- ENSP00000445117
- ENST00000539815
- ENSP00000439155
- ENST00000543356
- ENSP00000437765
- ENST00000642385
- ENSP00000494141
- GLCNE
- NM
- DMRV
- IBM2
- Uae1
- GLCNE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 1 | ||
molecular function | 0.99 | ||
kinase perturbation | 0.91 | ||
gene perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 441.87 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 226 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 441.87 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 226 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0