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Tbio
GNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Protein Summary
Description
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377902
  • ENSP00000367134
  • ENSG00000159921
  • ENST00000396594
  • ENSP00000379839
  • ENST00000447283
  • ENSP00000414760
  • ENST00000539208
  • ENSP00000445117
  • ENST00000539815
  • ENSP00000439155
  • ENST00000543356
  • ENSP00000437765
  • ENST00000642385
  • ENSP00000494141

Symbol
  • GLCNE
  • NM
  • DMRV
  • IBM2
  • Uae1
  • GLCNE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
molecular function
0.99
kinase perturbation
0.91
gene perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.36   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.36   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
C2orf68
Tdark
Novelty:  0.7947239
p_int:  0.999999886
p_ni:  1.12e-7
p_wrong:  3e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.999951299
p_ni:  5.65e-7
p_wrong:  0.000048136
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.999767485
p_ni:  0.0002325
p_wrong:  1.6e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
p_int:  0.999600422
p_ni:  0.000394337
p_wrong:  0.000005241
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZNF213
Tbio
Family:  TF
Novelty:  0.24190639
p_int:  0.999514229
p_ni:  0.000484464
p_wrong:  0.000001307
Data Source:  BioPlex
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.989
Data Source:  STRINGDB
RENBP
Tbio
Family:  Enzyme
Novelty:  0.02220005
Score:  0.987
Data Source:  STRINGDB
UAP1
Tbio
Family:  Enzyme
Novelty:  0.02034314
Score:  0.97
Data Source:  STRINGDB
NPL
Tbio
Family:  Enzyme
Novelty:  0.00944797
Score:  0.957
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Disease
Diseases associated with glycosylation precursor biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
1.8
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.8
1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
VGNC:8890
465094
Macaque
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
693525
Mouse
MGI:1354951
50798
Rat
RGD:69239
114711
Dog
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
VGNC:51721
481607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Macaque
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Mouse
Rat
Dog
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Publication Statistics
PubMed Score 358.36
PubMed score by year
PubTator Score 217.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title