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Tbio
DMTF1
Cyclin-D-binding Myb-like transcription factor 1

Protein Summary
Description
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331242
  • ENSP00000332171
  • ENSG00000135164
  • ENST00000394703
  • ENSP00000378193
  • ENST00000412139
  • ENSP00000407941
  • ENST00000425406
  • ENSP00000411908
  • ENST00000432937
  • ENSP00000412532
  • ENST00000447863
  • ENSP00000389774
  • ENST00000579677
  • ENSP00000464596
  • ENST00000584619
  • ENSP00000464092

Symbol
  • DMP1
  • DMP1
  • DMTF
  • MRUL
  • hDMP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
disease perturbation
0.87
virus perturbation
0.83
transcription factor
0.69
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.1   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.1   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
11.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin D binding myb like transcription factor 1
VGNC:7375
472434
Macaque
cyclin D binding myb like transcription factor 1
706292
Mouse
MGI:1344415
23857
Rat
RGD:70966
114485
Dog
cyclin D binding myb like transcription factor 1
VGNC:40004
475217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin D binding myb like transcription factor 1
Macaque
cyclin D binding myb like transcription factor 1
Mouse
Rat
Dog
cyclin D binding myb like transcription factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y222-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated transcriptional targets of AP1 family members Fra1 and Fra2
PathwayCommons: pid
AP-1 transcription factor network
Name
Explore in Pharos
Explore in Source
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (92)
1 – 10 of 92
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.757
Data Source: STRINGDB
PRPF40B
Tdark
Novelty: 0.04278291
Score: 0.755
Data Source: STRINGDB
ANPEP
Tchem
Family: Enzyme
Novelty: 0.0004182
Score: 0.716
Data Source: STRINGDB
RUNDC3B
Tbio
Novelty: 0.12462899
Score: 0.713
Data Source: STRINGDB
CCND2
Tbio
Novelty: 0.00157305
Score: 0.711
Data Source: STRINGDB
ABCB1
Tchem
Family: Transporter
Novelty: 0.00018144
Score: 0.706
Data Source: STRINGDB
TMEM243
Tdark
Novelty: 0.46282994
Score: 0.651
Data Source: STRINGDB
PNISR
Tdark
Novelty: 0.06559175
Score: 0.637
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
Score: 0.623
Data Source: STRINGDB
CDKN2A
Tbio
Novelty: 0.00014147
Score: 0.623
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.10

PubMed score by year
PubTator Score  11.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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