Tbio DMTF1 Cyclin-D-binding Myb-like transcription factor 1

Protein Summary

Description

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q9Y222
• B2RBE1
• B4DJS5
• Q05C48
• Q59G79
• Q6IS13
• Q969T2
• Q9H2Z2
• Q9H2Z3
• hDMTF1

Gene Name

• DMTF1

Ensembl ID

• ENST00000331242
• ENSP00000332171
• ENSG00000135164
• ENST00000394703
• ENSP00000378193
• ENST00000412139
• ENSP00000407941
• ENST00000425406
• ENSP00000411908
• ENST00000432937
• ENSP00000412532
• ENST00000447863
• ENSP00000389774
• ENST00000579677
• ENSP00000464596
• ENST00000584619
• ENSP00000464092

Symbol

• DMP1
• DMP1
• DMTF
• MRUL
• hDMP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
disease perturbation	0.87
virus perturbation	0.83
transcription factor	0.69
tissue sample	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.35   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.35   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0