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Tbio
NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

Protein Summary
Description
Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254940
  • ENSP00000254940
  • ENSG00000132603
  • ENST00000254941
  • ENSP00000254941

Symbol
  • KD93
  • CGI-37
  • HSPC031
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.91
disease perturbation
0.83
transcription factor binding site profile
0.82
interacting protein
0.81


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.51   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.51   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIP7, nucleolar pre-rRNA processing protein
VGNC:13745
454200
Mouse
MGI:1913414
66164
Rat
RGD:620069
192180
Dog
NIP7, nucleolar pre-rRNA processing protein
VGNC:43814
479673
Horse
NIP7, nucleolar pre-rRNA processing protein
VGNC:51267
100630672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIP7, nucleolar pre-rRNA processing protein
Mouse
Rat
Dog
NIP7, nucleolar pre-rRNA processing protein
Horse
NIP7, nucleolar pre-rRNA processing protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y221-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (404)
1 – 10 of 404
HINT3
Tdark
Novelty: 1.14285714
p_int: 0.999999858
p_ni: 1.42e-7
Data Source: BioPlex
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.91397348
p_ni: 0.08602652
Score: 0.906
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.881170293
p_ni: 0.118827501
p_wrong: 0.000002205
Score: 0.825
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.846237089
p_ni: 0.153762911
Score: 0.691
Data Source: BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.775142191
p_ni: 0.224857809
Score: 0.619
Data Source: BioPlex,STRINGDB
ARF5
Tbio
Family: Enzyme
Novelty: 0.02454098
p_int: 0.754029274
p_ni: 0.245970726
Data Source: BioPlex
NOP2
Tbio
Family: Enzyme
Novelty: 0.01664777
Score: 0.998
Data Source: STRINGDB
PES1
Tbio
Novelty: 0.07162845
Score: 0.997
Data Source: STRINGDB
NSA2
Tbio
Novelty: 0.04542275
Score: 0.997
Data Source: STRINGDB
WDR12
Tbio
Novelty: 0.03409059
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.51

PubMed score by year
PubTator Score  8.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer