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Tbio
JAG2
Protein jagged-2

Protein Summary
Description
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331782
  • ENSP00000328169
  • ENSG00000184916
  • ENST00000347004
  • ENSP00000328566

Symbol
  • HJ2
  • SER2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.87
kinase perturbation
0.84
PubMedID
0.75
transcription factor perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.19   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 444   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 488.19   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jagged 2
VGNC:3389
453210
Macaque
jagged 2
708991
Mouse
MGI:1098270
16450
Rat
RGD:2938
29147
Dog
jagged 2
VGNC:42173
490882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jagged 2
Macaque
jagged 2
Mouse
Rat
Dog
jagged 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y219-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (138)
1 – 10 of 138
VASN
Tbio
Novelty: 0.05424159
p_int: 0.99998421
p_ni: 0.000015567
p_wrong: 2.23e-7
Score: 0.164
Data Source: BioPlex,STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999610293
p_ni: 0.000389707
Data Source: BioPlex
PLPPR1
Tdark
Family: Enzyme
Novelty: 0.38109551
p_int: 0.998086974
p_ni: 0.00191302
p_wrong: 6e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.997757763
p_ni: 0.002242216
p_wrong: 2.1e-8
Data Source: BioPlex
STS
Tchem
Family: Enzyme
Novelty: 0.00324549
p_int: 0.997541032
p_ni: 0.00245894
p_wrong: 2.7e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
ADAM32
Tdark
Family: Enzyme
Novelty: 0.36071191
p_int: 0.982252907
p_ni: 0.017206138
p_wrong: 0.000540956
Score: 0.216
Data Source: BioPlex,STRINGDB
MFAP5
Tbio
Novelty: 0.01839035
p_int: 0.97880151
p_ni: 0.020964751
p_wrong: 0.000233738
Score: 0.327
Data Source: BioPlex,STRINGDB
TMEM87A
Tdark
Novelty: 0.33614983
p_int: 0.895156784
p_ni: 0.069018886
p_wrong: 0.03582433
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.887446159
p_ni: 0.083276706
p_wrong: 0.029277135
Score: 0.205
Data Source: BioPlex,STRINGDB
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.883338566
p_ni: 0.088497617
p_wrong: 0.028163818
Data Source: BioPlex
Publication Statistics
PubMed Score  488.19

PubMed score by year
PubTator Score  199.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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