Tbio JAG2 Protein jagged-2

Protein Summary

Description

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y219
• Q9UE17
• Q9UE99
• Q9UNK8
• Q9Y6P9
• Q9Y6Q0
• Jagged2

Gene Name

• JAG2

Ensembl ID

• ENST00000331782
• ENSP00000328169
• ENSG00000184916
• ENST00000347004
• ENSP00000328566

Symbol

• HJ2
• SER2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.87
kinase perturbation	0.84
PubMedID	0.75
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.4   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 444   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.4   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0