Tbio MTMR6 Myotubularin-related protein 6

Protein Summary

Description

Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.

Uniprot Accession IDs

• Q9Y217
• B2RBB5
• B3KSB4
• Q5JRG6
• Q86TB7
• Q86YH4
• Q96P80

Gene Name

• MTMR6

Ensembl ID

• ENST00000381801
• ENSP00000371221
• ENSG00000139505

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
transcription factor perturbation	0.91
microRNA	0.7
kinase perturbation	0.66
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Myotubularin-related Protein 6

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Myotubularin-related Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.51   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.51   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0