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Tbio
MTMR6
Myotubularin-related protein 6

Protein Summary
Description
Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381801
  • ENSP00000371221
  • ENSG00000139505
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.91
microRNA
0.7
kinase perturbation
0.66
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.92   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.92   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
27.3
triglyceride measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
27.3
triglyceride measurement
1
4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 6
VGNC:5082
452496
Macaque
myotubularin related protein 6
709118
Mouse
MGI:2145637
219135
Dog
myotubularin related protein 6
VGNC:43486
477336
Horse
myotubularin related protein 6
VGNC:20428
100058883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 6
Macaque
myotubularin related protein 6
Mouse
Dog
myotubularin related protein 6
Horse
myotubularin related protein 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y217-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (76)
1 – 10 of 76
MTMR7
Tbio
Family:  Enzyme
Novelty:  0.1707096
p_int:  0.999999874
p_ni:  1e-9
p_wrong:  1.25e-7
Score:  0.72
Data Source:  BioPlex,STRINGDB
MTMR9
Tbio
Novelty:  0.09702778
p_int:  0.999994386
p_ni:  0.000005614
p_wrong:  1e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
TTR
Tclin
Novelty:  0.0001199
p_int:  0.99999231
p_ni:  0.00000769
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999964083
p_ni:  0.000035891
p_wrong:  2.6e-8
Data Source:  BioPlex
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999936628
p_ni:  0.000063372
Score:  0.171
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999773908
p_ni:  0.000226087
p_wrong:  6e-9
Data Source:  BioPlex
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.998568537
p_ni:  0.00143146
p_wrong:  4e-9
Data Source:  BioPlex
DDHD1
Tbio
Family:  Enzyme
Novelty:  0.05209502
p_int:  0.997382567
p_ni:  0.00260831
p_wrong:  0.000009123
Data Source:  BioPlex
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
p_int:  0.993867425
p_ni:  0.006132531
p_wrong:  4.4e-8
Score:  0.552
Data Source:  BioPlex,STRINGDB
FHIT
Tchem
Family:  Enzyme
Novelty:  0.0012803
p_int:  0.993682701
p_ni:  0.006317285
p_wrong:  1.4e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.92

PubMed score by year
PubTator Score  4.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer