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Tbio
MTMR7
Myotubularin-related protein 7

Protein Summary
Description
Phosphatase that acts on lipids with a phosphoinositol headgroup. This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000180173
  • ENSP00000180173
  • ENSG00000003987
  • ENST00000521857
  • ENSP00000429733
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
protein domain
0.73
microRNA
0.64
tissue sample
0.63
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.54   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.54   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.3
38.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.3
38.5
Pathways (10)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Protein-Protein Interactions (67)
1 – 10 of 67
MTMR9
Tbio
Novelty: 0.09702778
p_int: 1
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
MTMR6
Tbio
Family: Enzyme
Novelty: 0.13067072
p_int: 0.999999874
p_ni: 1e-9
p_wrong: 1.25e-7
Score: 0.72
Data Source: BioPlex,STRINGDB
MTMR8
Tbio
Family: Enzyme
Novelty: 0.37417853
p_int: 0.999986938
p_ni: 1.67e-7
p_wrong: 0.000012895
Score: 0.828
Data Source: BioPlex,STRINGDB
RALGAPA2
Tdark
Family: Enzyme
Novelty: 0.12467725
p_int: 0.999946442
p_ni: 0.000053558
Score: 0.346
Data Source: BioPlex,STRINGDB
MIA3
Tbio
Novelty: 0.02784348
p_int: 0.990209726
p_ni: 0.009790274
Score: 0.165
Data Source: BioPlex,STRINGDB
TSR3
Tdark
Novelty: 0.09337944
p_int: 0.987532532
p_ni: 0.012467468
Score: 0.191
Data Source: BioPlex,STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
p_int: 0.857309764
p_ni: 0.142690236
Score: 0.23
Data Source: BioPlex,STRINGDB
PIKFYVE
Tchem
Family: Kinase
Novelty: 0.00441336
Score: 0.934
Data Source: STRINGDB
CDIPT
Tbio
Family: Enzyme
Novelty: 0.00560887
Score: 0.913
Data Source: STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
Score: 0.827
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.54

PubMed score by year
PubTator Score  1.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer