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Tbio
COLQ
Acetylcholinesterase collagenic tail peptide

Protein Summary
Description
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.94
gene perturbation
0.73
cell type or tissue
0.6
tissue sample
0.56
tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.5   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.5   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diverticular disease
1
1
0
1.1
59.9
1
1
0
1.3
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diverticular disease
0
1.1
59.9
0
1.3
45.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen like tail subunit of asymmetric acetylcholinesterase
VGNC:11971
743693
Mouse
MGI:1338761
382864
Rat
RGD:2377
29755
Horse
collagen like tail subunit of asymmetric acetylcholinesterase
VGNC:16757
100052475
Cow
collagen like tail subunit of asymmetric acetylcholinesterase
VGNC:27580
514615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen like tail subunit of asymmetric acetylcholinesterase
Mouse
Rat
Horse
collagen like tail subunit of asymmetric acetylcholinesterase
Cow
collagen like tail subunit of asymmetric acetylcholinesterase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y215-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (48)
1 – 10 of 48
P3H2
Tbio
Family: Enzyme
Novelty: 0.04237396
p_int: 0.999997452
p_ni: 0.000002539
p_wrong: 1e-8
Score: 0.166
Data Source: BioPlex,STRINGDB
FN1
Tchem
Novelty: 0.00003647
p_int: 0.999942337
p_ni: 0.000057663
Score: 0.17
Data Source: BioPlex,STRINGDB
TRIM68
Tbio
Family: Enzyme
Novelty: 0.11729189
p_int: 0.99993354
p_ni: 0.00006646
Data Source: BioPlex
P3H3
Tbio
Family: Enzyme
Novelty: 0.0010004
p_int: 0.99968181
p_ni: 0.00031819
Score: 0.195
Data Source: BioPlex,STRINGDB
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.999452332
p_ni: 0.000547637
p_wrong: 3.1e-8
Score: 0.86
Data Source: BioPlex,STRINGDB
CRTAP
Tbio
Novelty: 0.02380647
p_int: 0.999403913
p_ni: 0.000596087
Score: 0.313
Data Source: BioPlex,STRINGDB
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.999294694
p_ni: 0.000705306
Data Source: BioPlex
FBLN1
Tbio
Novelty: 0.00796703
p_int: 0.997730174
p_ni: 0.002269826
Score: 0.16
Data Source: BioPlex,STRINGDB
P3H4
Tbio
Novelty: 0.08407419
p_int: 0.997130432
p_ni: 0.002869568
Score: 0.663
Data Source: BioPlex,STRINGDB
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.991367803
p_ni: 0.008632197
Score: 0.553
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  81.50

PubMed score by year
PubTator Score  101.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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