Tchem TRPC6 Short transient receptor potential channel 6

Protein Summary

Description

Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9Y210
• Q52M59
• Q9HCW3
• Q9NQA8
• Q9NQA9
• TrpC6

Gene Name

• TRPC6

Ensembl ID

• ENST00000344327
• ENSP00000340913
• ENSG00000137672
• ENST00000348423
• ENSP00000343672
• ENST00000360497
• ENSP00000353687

Symbol

• TRP6
• TRP6
• FSGS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
molecular function	0.9
biological term	0.83
metabolite	0.82
gene perturbation	0.77

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Short Transient Receptor Potential Channel 6

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Strpc Subfamily / Trpc6 Sub-subfamily / Short Transient Receptor Potential Channel 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.43   (req: < 5)

Gene RIFs: 195   (req: <= 3)

Antibodies: 391   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 965.43   (req: >= 5)

Gene RIFs: 195   (req: > 3)

Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 58

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3